Exposure of NK cells to intravenous immunoglobulin induces IFN gamma release and degranulation but inhibits their cytotoxic activity

The mechanisms underlying the modulation of Natural Killer (NK) cell functions by intravenous immunoglobulin (IVIg) are poorly understood. Using an ex vivo whole blood assay system we demonstrate that IVIg suppresses NK cell cytotoxicity. This was paralleled by IVIg-induced degranulation of CD56(bri...

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Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 133(2009), 3 vom: 15. Dez., Seite 393-401
1. Verfasser: Jacobi, Christian (VerfasserIn)
Weitere Verfasser: Claus, Maren, Wildemann, Brigitte, Wingert, Sabine, Korporal, Mirjam, Römisch, Jürgen, Meuer, Stefan, Watzl, Carsten, Giese, Thomas
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antigens, CD Immunoglobulins, Intravenous Perforin 126465-35-8 Interferon-gamma 82115-62-6 Granzymes EC 3.4.21.-