Modulation of ascorbic acid metabolism by cytochrome P450 induction revealed by metabonomics and transcriptional profiling

In the present study, NMR-based urinary metabonomic profiles resulting from dosing with widely recognized microsomal enzyme inducers were evaluated in male rats. Wistar or Sprague-Dawley rats were dosed daily by oral gavage with phenobarbital (PB; 100 mg/kg), diallyl sulfide (DAS; 500 mg/kg), the in...

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Veröffentlicht in:Magnetic resonance in chemistry : MRC. - 1985. - 47 Suppl 1(2009) vom: 20. Dez., Seite S12-9
1. Verfasser: Aranibar, Nelly (VerfasserIn)
Weitere Verfasser: Bhaskaran, Vasanthi, Ott, Karl-Heinz, Vassallo, Jeff, Nelson, David, Lecureux, Lloyd, Gong, Lei, Stryker, Steve, Lehman-McKeeman, Lois
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:Magnetic resonance in chemistry : MRC
Schlagworte:Comparative Study Journal Article Allyl Compounds Sugar Acids Sulfides gulonic acid 20246-33-7 allyl sulfide 60G7CF7CWZ Cytochrome P-450 Enzyme System mehr... 9035-51-2 Ascorbic Acid PQ6CK8PD0R Phenobarbital YQE403BP4D