AA28-67 domain within MyD88 suppresses c-myc activity and expression to regulate differentiation and function of dendritic cells

The mechanism by which c-myc expression in undifferentiated cells rapidly declines following induction of differentiation is poorly characterized. We demonstrate here that MyD88, which can activate NF-kappaB and MAPK, also suppresses c-myc activity and expression. The aa 28-67 domain, a highly conse...

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Publié dans:	Clinical immunology (Orlando, Fla.). - 1999. - 133(2009), 3 vom: 15. Dez., Seite 324-32
Auteur principal:	Zhang, Zhuohan (Auteur)
Autres auteurs:	Zeng, Bin, Jiao, Guohui, Li, Yuhao, Liu, Yu, Zhang, Yuan, Yang, Rongcun
Format:	Article en ligne
Langue:	English
Publié:	2009
Accès à la collection:	Clinical immunology (Orlando, Fla.)
Sujets:	Journal Article Research Support, Non-U.S. Gov't Myc protein, mouse Myd88 protein, mouse Myeloid Differentiation Factor 88 Proto-Oncogene Proteins c-myc RNA, Small Interfering RNA 63231-63-0