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01000naa a22002652 4500 |
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NLM191007129 |
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DE-627 |
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cr uuu---uuuuu |
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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2009.05.001
|2 doi
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|a pubmed24n0637.xml
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|a (DE-627)NLM191007129
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|a eng
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| 100 |
1 |
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|a Ardeniz, Omür
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Granulomatous disease in common variable immunodeficiency
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|c 2009
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 08.12.2009
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|a Date Revised 10.04.2022
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|a published: Print-Electronic
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|a CommentIn: Clin Immunol. 2010 Mar;134(3):359-60. - PMID 20018565
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|a Citation Status MEDLINE
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|a Granulomatous disease occurs in 8-22% of patients with common variable immunodeficiency (CVID). We examined the clinical and immunologic information of all 37 of 455 (8.1%) CVID subjects with this complication. The median age at diagnosis of CVID was 26 (2-59). 14 had granulomas 1-18 years before diagnosis of CVID. In 6 detection of granulomas coincided with this diagnosis; for 17, granulomas were documented later. 54% had lung granulomas, 43% in lymph nodes and 32% in liver. 54% of the group had had autoimmune diseases, mostly immune thrombocytopenia and hemolytic anemia. 24% had had a splenectomy. Nineteen (51.3%) required steroid treatment for granulomas; other immune suppressants were used in some. Over 25 years 28.5% died (median age 37.5), but not significantly more when compared to our CVID patients without granulomas (19.8%). Those with lung granulomas had similar mortality to those with granulomas in other tissues
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Antibodies
|2 NLM
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| 650 |
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|a Mitogens
|2 NLM
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| 700 |
1 |
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|a Cunningham-Rundles, Charlotte
|e verfasserin
|4 aut
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 133(2009), 2 vom: 15. Nov., Seite 198-207
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|g volume:133
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|g month:11
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|u http://dx.doi.org/10.1016/j.clim.2009.05.001
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