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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1021/la9008834
|2 doi
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|a pubmed25n0636.xml
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|a (DE-627)NLM190908556
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|a (NLM)19705896
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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1 |
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|a Fukui, Yuuka
|e verfasserin
|4 aut
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|a The preparation of sugar polymer-coated nanocapsules by the layer-by-layer deposition on the liposome
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|c 2009
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 03.11.2009
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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|a We intended to combine the liposomal preparation and the layer-by-layer deposition to prepare a nanosized capsule. Chitosan (CHI) was deposited to form the cationic polymeric layer onto a negatively charged liposomal surface and further deposition was carried out using anionic polymers dextran sulfate (DXS) or deoxyribonucleic acid (DNA). zeta-Potentials of nanocapsules changed between positive and negative charges at each deposition. FE-TEM revealed that the liposome remained a spherical shape even after the layer-by-layer (LbL) deposition. The capsule wall showed a dramatic increase in stability against the surfactant Triton X-100 compared to a bare liposome, and the stability was controllable by the adsorption amount of the polymer. These suggest that the polymer multilayer was generated on the liposome surface by the layer-by-layer depositions of polysaccharides. The three kinds of chemical substances with different charges, 1-hydroxy pyrene-3,6,8-trisulfonic acid (HPTS), alendronate, and glucose, were encapsulated into nanocapsules and the release was suppressed by the polymeric capsule wall irrespective of charges. The release from DNA-deposited nanocapsules (liponano-CHI-DNA) was clearly increased by raising temperature from 25 to 60 degrees C. This indicates that the temperature-dependent release was achieved by applying DNA denaturation as a temperature-dependent "switch", which influenced the permeability of the capsule wall
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Carbohydrates
|2 NLM
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|a Cations
|2 NLM
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|a Detergents
|2 NLM
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|a Liposomes
|2 NLM
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|a Nanocapsules
|2 NLM
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|a Polymers
|2 NLM
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|a Surface-Active Agents
|2 NLM
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|a Octoxynol
|2 NLM
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| 650 |
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|a 9002-93-1
|2 NLM
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| 650 |
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|a Glucose
|2 NLM
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| 650 |
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|a IY9XDZ35W2
|2 NLM
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| 650 |
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|a Alendronate
|2 NLM
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| 650 |
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|a X1J18R4W8P
|2 NLM
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| 700 |
1 |
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|a Fujimoto, Keiji
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1991
|g 25(2009), 17 vom: 01. Sept., Seite 10020-5
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:25
|g year:2009
|g number:17
|g day:01
|g month:09
|g pages:10020-5
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|u http://dx.doi.org/10.1021/la9008834
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