The effects of electro-acupuncturing at Zusanli point on intestinal proinflammatory factors, diamine oxidase and tissue water content in rats with sepsis

OBJECTIVE: To investigate the protective effect of electro-acupuncturing (EA) at Zusanli point on sepsis induced ischemic and oxygen free radical intestinal injury in rats with sepsis

Bibliographische Detailangaben
Veröffentlicht in:Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. - 1998. - 21(2009), 8 vom: 21. Aug., Seite 485-7
1. Verfasser: Hu, Sen (VerfasserIn)
Weitere Verfasser: Zhang, Li-jian, Bai, Hui-ying, Bao, Cheng-mei
Format: Aufsatz
Sprache:Chinese
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Free Radicals Malondialdehyde 4Y8F71G49Q Amine Oxidase (Copper-Containing) EC 1.4.3.21
LEADER 01000caa a22002652 4500
001 NLM19080694X
003 DE-627
005 20250210171627.0
007 tu
008 231223s2009 xx ||||| 00| ||chi c
028 5 2 |a pubmed25n0636.xml 
035 |a (DE-627)NLM19080694X 
035 |a (NLM)19695173 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a chi 
100 1 |a Hu, Sen  |e verfasserin  |4 aut 
245 1 4 |a The effects of electro-acupuncturing at Zusanli point on intestinal proinflammatory factors, diamine oxidase and tissue water content in rats with sepsis 
264 1 |c 2009 
336 |a Text  |b txt  |2 rdacontent 
337 |a ohne Hilfsmittel zu benutzen  |b n  |2 rdamedia 
338 |a Band  |b nc  |2 rdacarrier 
500 |a Date Completed 06.05.2010 
500 |a Date Revised 01.12.2018 
500 |a published: Print 
500 |a Citation Status MEDLINE 
520 |a OBJECTIVE: To investigate the protective effect of electro-acupuncturing (EA) at Zusanli point on sepsis induced ischemic and oxygen free radical intestinal injury in rats with sepsis 
520 |a METHODS: Thirty-two male Wistar rats were used to reproduce sepsis by cecal ligation and puncture (CLP), and they were randomly divided into four groups (each n=8): CLP+EA (CLP/EA), CLP+sham EA (CLP/SEA), vagotomy+CLP+SEA (VA/CLP/SEA) and vagotomy+CLP+EA (VA/CLP/EA). Zusanli point was electro-acupunctured with constant voltage (2-100 Hz,2 mA for 30 minutes) immediately after CLP surgery. Abdominal vagotomy was performed in rats in VA/CL/SEA and VA/CLP/SEA groups. Six hours after CLP, the mucosal blood flow of jejunum (JMBF) was measured. Animals were sacrificed after 6 hours and specimens of jejunum were harvested for evaluation of malondialdehyde (MDA), xanthine oxidase (XOD), diamine oxidase (DAO) and assessment of the water content (WCR) 
520 |a RESULTS: JMBF and the activity of DAO of CLP/EA group were markedly higher, and the levels of XOD, MDA and WCR in jejunal tissue were obviously lower than those of CLP/SEA group (all P<0.05). The levels of JMBF and DAO of the VA/CLP/SEA group and VA/CLP/EA group were significantly lower, and XOD, MDA and WCR obviously higher than those of the CLP/EA group ( all P<0.05 ). There were no statistically differences in all above measurements between the VA/CLP/EA group and the VA/CLP/SEA group (all P>0.05) 
520 |a CONCLUSION: The results indicate that EA at Zusanli point obviously increased JMBF and DAO, and alleviated tissue edema and insult of intestinal mucosa. Vagotomy could weaken or eliminate the effects of EA. It is suggested that cholinergic anti-inflammatory pathway is one of the main mechanisms of intestinal protective effect of EA at Zusanli point 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 7 |a Free Radicals  |2 NLM 
650 7 |a Malondialdehyde  |2 NLM 
650 7 |a 4Y8F71G49Q  |2 NLM 
650 7 |a Amine Oxidase (Copper-Containing)  |2 NLM 
650 7 |a EC 1.4.3.21  |2 NLM 
700 1 |a Zhang, Li-jian  |e verfasserin  |4 aut 
700 1 |a Bai, Hui-ying  |e verfasserin  |4 aut 
700 1 |a Bao, Cheng-mei  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue  |d 1998  |g 21(2009), 8 vom: 21. Aug., Seite 485-7  |w (DE-627)NLM098227793  |x 1003-0603  |7 nnns 
773 1 8 |g volume:21  |g year:2009  |g number:8  |g day:21  |g month:08  |g pages:485-7 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 21  |j 2009  |e 8  |b 21  |c 08  |h 485-7