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20231223185527.0 |
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cr uuu---uuuuu |
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231223s2009 xx |||||o 00| ||eng c |
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7 |
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|a 10.1016/j.clim.2009.07.010
|2 doi
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|a pubmed24n0635.xml
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|a (DE-627)NLM19054984X
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|a (NLM)19665434
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Ni, Zhenya
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Cutaneous lymphocyte-associated antigen (CLA) T cells up-regulate P-selectin ligand expression upon their activation
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1 |
|c 2009
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 08.12.2009
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| 500 |
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Memory T cells expressing CLA occur in humans and accumulate in normal and inflamed skin. These cells uniformly bind to the vascular adhesion molecule E-selectin, yet only a subset binds to P-selectin. The latter cells are distinguished by the mAb CHO-131, and are enriched in psoriasis lesions. Activated T cells up-regulate CLA expression, but little is currently known about their binding to P-selectin. We observed that CLA(+) CD4(+) T cells derived from stimulated naive T cells uniformly express the CHO-131 epitope. This occurred as well upon the restimulation of memory CLA(+) CD4(+) T cells. The latter cells also expressed higher levels of PSGL-1 modified by P-selectin glycan ligands; C2GlcNAcT-1 mRNA, a glycosyltransferase critical for such glycan synthesis; and more uniformly bound to P-selectin. Our findings thus indicate that unlike memory CLA(+) CD4(+) T cells, when activated these cells can broadly bind to P-selectin, suggesting a more diverse tissue trafficking capacity
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| 650 |
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|a Journal Article
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| 650 |
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|a Research Support, N.I.H., Extramural
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| 650 |
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7 |
|a Antibodies, Monoclonal
|2 NLM
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| 650 |
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7 |
|a Antigens, Differentiation, T-Lymphocyte
|2 NLM
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| 650 |
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7 |
|a Antigens, Neoplasm
|2 NLM
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| 650 |
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7 |
|a CD3 Complex
|2 NLM
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| 650 |
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|a CTAGE1 protein, human
|2 NLM
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| 650 |
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7 |
|a CY 1503
|2 NLM
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| 650 |
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7 |
|a Epitopes
|2 NLM
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| 650 |
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|a Interleukin-2
|2 NLM
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| 650 |
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7 |
|a Membrane Glycoproteins
|2 NLM
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| 650 |
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7 |
|a Oligosaccharides
|2 NLM
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| 650 |
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7 |
|a P-selectin ligand protein
|2 NLM
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| 650 |
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7 |
|a N-Acetylglucosaminyltransferases
|2 NLM
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| 650 |
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7 |
|a EC 2.4.1.-
|2 NLM
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| 650 |
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7 |
|a beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-acetylglucosaminyl transferase
|2 NLM
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| 650 |
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7 |
|a EC 2.4.1.102
|2 NLM
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| 700 |
1 |
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|a Walcheck, Bruce
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 133(2009), 2 vom: 01. Nov., Seite 257-64
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:133
|g year:2009
|g number:2
|g day:01
|g month:11
|g pages:257-64
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2009.07.010
|3 Volltext
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|d 133
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|h 257-64
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