A tolerogenic peptide that induces suppressor of cytokine signaling (SOCS)-1 restores the aberrant control of IFN-gamma signaling in lupus-affected (NZB x NZW)F1 mice

Interferon-gamma (IFN-gamma) plays a pathogenic role in systemic lupus erythematosus (SLE). Uncontrolled IFN-gamma signaling may result from a deficiency in the negative regulator, namely, suppressor of cytokine signaling-1 (SOCS-1). We investigated the activation status of IFN-gamma signaling pathw...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 133(2009), 1 vom: 01. Okt., Seite 61-8
1. Verfasser: Sharabi, Amir (VerfasserIn)
Weitere Verfasser: Sthoeger, Zev M, Mahlab, Keren, Lapter, Smadar, Zinger, Heidy, Mozes, Edna
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Autoantigens CDR1 protein, human Nerve Tissue Proteins Peptides STAT1 Transcription Factor Socs1 protein, mouse Stat1 protein, mouse Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins mehr... Interferon-gamma 82115-62-6