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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2009.06.008
|2 doi
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|a pubmed25n0634.xml
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|a (DE-627)NLM190170093
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|a (NLM)19625220
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Hammons, Andrea L
|e verfasserin
|4 aut
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|a Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1
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|c 2009
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 08.10.2009
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that recruits monocytes into the subendothelial cell layer in atherosclerotic lesions. Elevated homocysteine (hyperhomocysteinemia), which is usually associated with low-folate status, is a known risk factor for many pathologies with inflammatory etiologies. The present study was undertaken to examine whether there are associations between MCP-1 concentrations and folate/Hcy phenotype or methylenetetrahydrofolate reductase (MTHFR) 677C>T genotype in healthy young adults. In females, MCP-1 concentrations were positively correlated with Hcy and negatively correlated with both serum and red blood cell folate; female smokers and MTHFR 677T carriers had particularly elevated MCP-1 concentrations. Similar relationships were not seen in males. These findings may have implications for understanding the female predominance observed for a range of autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Chemokine CCL2
|2 NLM
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| 650 |
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|a Homocysteine
|2 NLM
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| 650 |
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|a 0LVT1QZ0BA
|2 NLM
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| 650 |
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|a Folic Acid
|2 NLM
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| 650 |
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|a 935E97BOY8
|2 NLM
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| 650 |
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|a Methylenetetrahydrofolate Reductase (NADPH2)
|2 NLM
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| 650 |
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7 |
|a EC 1.5.1.20
|2 NLM
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| 700 |
1 |
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|a Summers, Carolyn M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Woodside, Jayne V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a McNulty, Helene
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Strain, J J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Young, Ian S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Murray, Liam
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Boreham, Colin A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Scott, John M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mitchell, Laura E
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Whitehead, Alexander S
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 133(2009), 1 vom: 01. Okt., Seite 132-7
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
1 |
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|g volume:133
|g year:2009
|g number:1
|g day:01
|g month:10
|g pages:132-7
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2009.06.008
|3 Volltext
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|d 133
|j 2009
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|h 132-7
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