T cell receptor signaling induced by an analog peptide of type II collagen requires activation of Syk

We have previously described an analog peptide of type II collagen (CII) that can suppress collagen-induced arthritis (CIA). This analog peptide represents CII(245-270), the immunodominant epitope of CII, but with substitutions at 260, 261, and 263 - CII(245-270) (A(260), B(261), and N(263)) (A9). T...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 133(2009), 1 vom: 01. Okt., Seite 145-53
1. Verfasser:	Tang, Bo (VerfasserIn)
Weitere Verfasser:	Zhou, Jing, Park, Jeoung-Eun, Cullins, David, Yi, Ae-Kyung, Kang, Andrew H, Stuart, John M, Myers, Linda K
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2009
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Collagen Type II Cytokines GATA3 Transcription Factor Gata3 protein, mouse Intracellular Signaling Peptides and Proteins Oligopeptides mehr... Receptors, Antigen, T-Cell Stilbenes Sulfonamides 3,3',4,5'-tetrahydroxystilbene 6KS3LS0D4F Protein-Tyrosine Kinases EC 2.7.10.1 Syk Kinase EC 2.7.10.2 Syk protein, mouse Extracellular Signal-Regulated MAP Kinases EC 2.7.11.24 JNK Mitogen-Activated Protein Kinases p38 Mitogen-Activated Protein Kinases