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231223s2009 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1021/la9014338
|2 doi
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|a pubmed24n0633.xml
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|a (DE-627)NLM18981909X
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|a (NLM)19583223
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Xie, Yu-Liang
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Preparation and characterization of biocompatible microcapsules of sodium cellulose sulfate/chitosan by means of layer-by-layer self-assembly
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|c 2009
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 13.10.2009
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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|a A novel microcapsule system composed of sodium cellulose sulfate (NaCS) and chitosan was prepared by layer-by-layer (LbL) self-assembly technique. As a potential drug delivery system, it had several advantages in biocompatibility and biodegradation due to its use of natural polysaccharides. Some parameters in the preparation of the microcapsule, such as layers in the LbL process (up to 20 layers), chitosan viscosities (50, 100, and 200 mPas), outmost layer materials (NaCS or chitosan), and NaCl concentrations (0 M, 0.5 M, 1 M), were investigated to better understand their effects on the LbL process. A novel method for removing the core templates PLA and CaCO3 from the formed core-shell structure was proposed by addition of N-methyl pyrrolidone or EDTA-Na. This preparation process was well observed by a microscope-camera system. The hollow microcapsules were tested by scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM) and scanning probe microscopy (SPM) to characterize their size, morphology, and surface. The results showed that the shell thickness of microcapsules was about 6 nm, and the average thickness of one layer of NaCS/chitosan polyelectrolyte complex was 1.5 nm. The molecular weight cutoff in sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) showed about 70 kDa by using of diffusion test with the cell lysate of Escherichia coli
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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7 |
|a Biocompatible Materials
|2 NLM
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7 |
|a Capsules
|2 NLM
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| 650 |
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|a Drug Carriers
|2 NLM
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| 650 |
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7 |
|a Water
|2 NLM
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| 650 |
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7 |
|a 059QF0KO0R
|2 NLM
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|a Cellulose
|2 NLM
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| 650 |
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7 |
|a 9004-34-6
|2 NLM
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| 650 |
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|a Chitosan
|2 NLM
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| 650 |
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|a 9012-76-4
|2 NLM
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| 650 |
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7 |
|a cellulose sulfate
|2 NLM
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| 650 |
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7 |
|a 9032-43-3
|2 NLM
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| 700 |
1 |
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|a Wang, Ming-Jun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yao, Shan-Jing
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 25(2009), 16 vom: 18. Aug., Seite 8999-9005
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:25
|g year:2009
|g number:16
|g day:18
|g month:08
|g pages:8999-9005
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4 |
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|u http://dx.doi.org/10.1021/la9014338
|3 Volltext
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