Clinical report on diagnosis and treatment of 14 cases with pediatric Ewing's sarcoma family tumors

OBJECTIVE: To recognize and improve the outcome of childhood Ewing's sarcoma family tumors, and to identify the efficacy and safety of the chemotherapy using RS-2002 Protocol

Bibliographische Detailangaben
Veröffentlicht in:Zhonghua er ke za zhi = Chinese journal of pediatrics. - 1960. - 47(2009), 3 vom: 03. März, Seite 179-82
1. Verfasser: Pan, Ci (VerfasserIn)
Weitere Verfasser: Tang, Jing-yan, Xue, Hui-liang, Chen, Jing, Dong, Lu, Zhou, Min, Ye, Qi-dong, Wang, Yao-ping
Format: Aufsatz
Sprache:Chinese
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:Zhonghua er ke za zhi = Chinese journal of pediatrics
Schlagworte:English Abstract Journal Article
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245 1 0 |a Clinical report on diagnosis and treatment of 14 cases with pediatric Ewing's sarcoma family tumors 
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520 |a OBJECTIVE: To recognize and improve the outcome of childhood Ewing's sarcoma family tumors, and to identify the efficacy and safety of the chemotherapy using RS-2002 Protocol 
520 |a METHODS: From September 1997 to September 2006, 14 newly diagnosed patients with the tumors were admitted, 9 were boys, and 5 were girls, the median age was 7.04 years, ranging from 1.58 years to 11.67 years. Among them, 9 patients were younger than 10 years. By the time of diagnosis, 9 patients had local diseases, and the other 5 patients had metastatic diseases. All the patients' diagnoses were confirmed by pathological studies. Nine patients had Ewing's sarcoma by histology, and the other 5 patients had peripheral primitive neuroectodermal tumors (PPNET). All of the patients were treated with multidisciplinary therapy, and RS-2002 Protocol for chemotherapy was used to treat patients with rhabdomyosarcoma in our hospital. Surgery and irradiation were performed for local control. Imaging studies were used for evaluation, reevaluation and follow-up 
520 |a RESULTS: Till April 30th 2007, 13/14 patients survived. The median follow-up time was 41 months (range: 7 months-115 months). The 10-year overall survival (OS) was 88.9%+/-10.5%, and the 10-year disease-free-survival (DFS) was 72.2%+/-13.8%; 3/14 patients had disease relapse, the median time to relapse from initial diagnosis was 23 months (range: 16-30 months). One patient developed second malignancy. No therapy related death was documented 
520 |a CONCLUSIONS: Childhood Ewing's sarcoma family tumors were not very rare, and the prognosis was acceptable with optimal treatment. RS-2002 Protocol was effective and safe in treating such patients 
650 4 |a English Abstract 
650 4 |a Journal Article 
700 1 |a Tang, Jing-yan  |e verfasserin  |4 aut 
700 1 |a Xue, Hui-liang  |e verfasserin  |4 aut 
700 1 |a Chen, Jing  |e verfasserin  |4 aut 
700 1 |a Dong, Lu  |e verfasserin  |4 aut 
700 1 |a Zhou, Min  |e verfasserin  |4 aut 
700 1 |a Ye, Qi-dong  |e verfasserin  |4 aut 
700 1 |a Wang, Yao-ping  |e verfasserin  |4 aut 
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