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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1021/la901602w
|2 doi
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|a pubmed24n0632.xml
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|a (DE-627)NLM189718439
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|a (NLM)19572525
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Maurizi, L
|e verfasserin
|4 aut
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|a Easy route to functionalize iron oxide nanoparticles via long-term stable thiol groups
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|c 2009
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 13.10.2009
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|a Date Revised 19.11.2015
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|a published: Print
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|a Citation Status MEDLINE
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|a The functionalization of superparamagnetic iron oxide nanoparticles (SPIOs) by meso-2,3-dimercaptosuccinic acid (DMSA) was investigated. Under ambient conditions, the thiol groups from DMSA are not stable and do not allow a direct functionalization without storage in stringent conditions or a chemical regeneration of free thiols. In this study, we have developed a protocol based on poly(ethylene glycol) (PEG) grafting of SPIO prior to DMSA anchoring. We have observed that PEG helps to increase the stability of thiol groups under ambient conditions. The thiol functionalized SPIOs were stable under physiological pH and ionic strength as determined by Ellman's essay and allowed us to graft a thiol reactive fluorescent dye: tetramethylrhodamine-5-maleimide (TMRM)
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Ferric Compounds
|2 NLM
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|a Sulfhydryl Compounds
|2 NLM
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|a ferric oxide
|2 NLM
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|a 1K09F3G675
|2 NLM
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|a Succimer
|2 NLM
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|a DX1U2629QE
|2 NLM
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|a Bisht, H
|e verfasserin
|4 aut
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|a Bouyer, F
|e verfasserin
|4 aut
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|a Millot, N
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 25(2009), 16 vom: 18. Aug., Seite 8857-9
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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|g volume:25
|g year:2009
|g number:16
|g day:18
|g month:08
|g pages:8857-9
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|u http://dx.doi.org/10.1021/la901602w
|3 Volltext
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