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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1021/la9018794
|2 doi
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|a pubmed24n0632.xml
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|a (DE-627)NLM189718285
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|a (NLM)19572509
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Wang, Jie
|e verfasserin
|4 aut
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|a High-frequency ultrasound-responsive block copolymer micelle
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|c 2009
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 21.01.2010
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|a Date Revised 01.12.2018
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|a published: Print
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|a Citation Status MEDLINE
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|a Micelles of a diblock copolymer composed of poly(ethylene oxide) and poly(2-tetrahydropyranyl methacrylate) (PEO-b-PTHPMA) in aqueous solution could be disrupted by high-frequency ultrasound (1.1 MHz). It was found that, upon exposure to a high-intensity focused ultrasound (HIFU) beam at room temperature, the pH value of the micellar solution decreased over irradiation time. The infrared spectroscopic analysis of solid block copolymer samples collected from the ultrasound irradiated micellar solution revealed the formation of carboxylic acid dimers and hydroxyl groups. These characterization results suggest that the high-frequency HIFU beam could induce the hydrolysis reaction of THPMA at room temperature resulting in the cleavage of THP groups. The disruption of PEO-b-PTHPMA micelles by ultrasound was investigated by using dynamic light scattering, atomic force microscopy, and fluorescence spectroscopy. On the basis of the pH change, it was found that the disruption process was determined by a number of factors such as the ultrasound power, the micellar solution volume and the location of the focal spot of the ultrasound beam. This study shows the potential to develop ultrasound-sensitive block copolymer micelles by having labile chemical bonds in the polymer structure, and to use the high-frequency HIFU to trigger a chemical reaction for the disruption of micelles
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Micelles
|2 NLM
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|a Polymers
|2 NLM
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|a Polyethylene Glycols
|2 NLM
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| 650 |
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|a 3WJQ0SDW1A
|2 NLM
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| 700 |
1 |
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|a Pelletier, Maxime
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Hongji
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xia, Hesheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Yue
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 25(2009), 22 vom: 17. Nov., Seite 13201-5
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:25
|g year:2009
|g number:22
|g day:17
|g month:11
|g pages:13201-5
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|u http://dx.doi.org/10.1021/la9018794
|3 Volltext
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