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DE-627 |
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20231223183737.0 |
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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1111/j.1939-165X.2009.00162.x
|2 doi
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|a pubmed24n0632.xml
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|a (DE-627)NLM189497874
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|a (NLM)19548968
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Clancey, Noel
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Effects of in vitro hemodilution of canine blood on platelet function analysis using the PFA-100
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|c 2009
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 17.08.2010
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|a Date Revised 20.10.2016
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a BACKGROUND: The platelet function analyzer (PFA)-100 is a point-of-care instrument previously evaluated in humans and dogs. In both species, artificially prolonged platelet closure time (CT) occurs with anemia. Reliability of the analyzer in dogs becomes a concern when the HCT is between 0.25 and 0.35 L/L
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|a OBJECTIVE: The objective of this study was to further define the level of HCT at which CT is prolonged, using in vitro diluted canine blood
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|a METHODS: Citrated whole blood samples were collected from 22 healthy dogs. Initial HCT was determined and autologous platelet-rich plasma was added to samples to achieve HCTs of 0.33, 0.30, and 0.27 L/L. CT was determined in duplicate on the PFA-100 using collagen/adenosine-5'-diphosphate cartridges
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|a RESULTS: Compared with the initial CT in samples with HCT 0.39-0.54 L/L (CT mean+/-SD=57.8+/-5.75 seconds), significantly prolonged CTs were found in hemodiluted samples with HCT 0.33 L/L (61.1+/-4.64 seconds), 0.30 L/L (64.3+/-6.79 seconds), and 0.27 L/L (70.8+/-7.90 seconds) (P=0.029; repeated measures ANOVA)
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|a CONCLUSION: Although statistical differences were found, further studies are needed to determine the clinical significance of the mild prolongation in CT associated with mild anemia. Until then, dogs with HCTs slightly <0.35 L/L should be evaluated cautiously for platelet dysfunction using the PFA-100
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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1 |
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|a Burton, Shelley
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Horney, Barbara
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mackenzie, Allan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nicastro, Andrea
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Côté, Etienne
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 38(2009), 4 vom: 01. Dez., Seite 467-70
|w (DE-627)NLM098159984
|x 1939-165X
|7 nnns
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| 773 |
1 |
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|g volume:38
|g year:2009
|g number:4
|g day:01
|g month:12
|g pages:467-70
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|u http://dx.doi.org/10.1111/j.1939-165X.2009.00162.x
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