Upregulated BclG(L) expression enhances apoptosis of peripheral blood CD4+ T lymphocytes in patients with systemic lupus erythematosus

Upregulated BclG(L) expression enhances apoptosis of peripheral blood CD4+ T lymphocytes in patients with systemic lupus erythematosus

Increased lymphocyte apoptosis has been suggested to contribute to the development of systemic lupus erythematosus (SLE), but the critical factors involved in the apoptotic pathways are still unknown. By long serial analysis of gene expression (LongSAGE) profiles and microarray analyses, a novel apo...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 132(2009), 3 vom: 15. Sept., Seite 349-61
1. Verfasser: Luo, Na (VerfasserIn)
Weitere Verfasser: Wu, Yi, Chen, Yongwen, Yang, Zhao, Guo, Sheng, Fei, Lei, Zhou, Di, Yang, Chengying, Wu, Shengxi, Ni, Bing, Hao, Fei, Wu, Yuzhang
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antibodies, Antinuclear BCL2L14 protein, human Proto-Oncogene Proteins c-bcl-2 RNA, Small Interfering
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520 |a Increased lymphocyte apoptosis has been suggested to contribute to the development of systemic lupus erythematosus (SLE), but the critical factors involved in the apoptotic pathways are still unknown. By long serial analysis of gene expression (LongSAGE) profiles and microarray analyses, a novel apoptosis-related gene BclG(L) expression was found significantly increased in peripheral blood CD4+ T cells of SLE patients, which was correlated with the enhanced CD4+ T cells apoptosis, anti-nuclear antibody (ANA) titer and proteinuria. In vitro, BclG(L) expression could be specially upregulated by SLE serum stimulation and positively correlated with induced CD4+ T cell apoptosis. Enforcing BclG(L) overexpression by lentivirus could directly enhance CD4+ T cell apoptosis, but these apoptosis-inducing effects could be partially inhibited by knockdown of BclG(L) expression. Collectively, these results indicate that increased BclG(L) expression may contribute to the aberrant CD4+ T cell apoptosis which causes an inappropriate immune response and impaired homeostasis in SLE 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 7 |a Antibodies, Antinuclear  |2 NLM 
650 7 |a BCL2L14 protein, human  |2 NLM 
650 7 |a Proto-Oncogene Proteins c-bcl-2  |2 NLM 
650 7 |a RNA, Small Interfering  |2 NLM 
700 1 |a Wu, Yi  |e verfasserin  |4 aut 
700 1 |a Chen, Yongwen  |e verfasserin  |4 aut 
700 1 |a Yang, Zhao  |e verfasserin  |4 aut 
700 1 |a Guo, Sheng  |e verfasserin  |4 aut 
700 1 |a Fei, Lei  |e verfasserin  |4 aut 
700 1 |a Zhou, Di  |e verfasserin  |4 aut 
700 1 |a Yang, Chengying  |e verfasserin  |4 aut 
700 1 |a Wu, Shengxi  |e verfasserin  |4 aut 
700 1 |a Ni, Bing  |e verfasserin  |4 aut 
700 1 |a Hao, Fei  |e verfasserin  |4 aut 
700 1 |a Wu, Yuzhang  |e verfasserin  |4 aut 
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773 1 8 |g volume:132  |g year:2009  |g number:3  |g day:15  |g month:09  |g pages:349-61 
856 4 0 |u http://dx.doi.org/10.1016/j.clim.2009.05.010  |3 Volltext 
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