Changes in autoreactive T cell avidity during type 1 diabetes development
The activation threshold for antigen-specific T cell responses is dependent on the avidity of the trimolecular interaction between TCR, antigen, and MHC. We compared CD4+ T cell avidities for the diabetes-associated autoantigen glutamic acid decarboxylase 555-567 (GAD 555) among serial samples from...
Ausführliche Beschreibung
Bibliographische Detailangaben
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 132(2009), 3 vom: 01. Sept., Seite 312-20
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| 1. Verfasser: |
Standifer, Nathan E
(VerfasserIn) |
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| Weitere Verfasser: |
Burwell, Emily A,
Gersuk, Vivian H,
Greenbaum, Carla J,
Nepom, Gerald T |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2009
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| Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.)
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| Schlagworte: | Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Antigens, CD
Hemagglutinin Glycoproteins, Influenza Virus
Insulin
Interleukin-15 Receptor alpha Subunit
Receptors, Antigen, T-Cell
Receptors, Antigen, T-Cell, alpha-beta
Interferon-gamma
mehr...
82115-62-6
Receptor-Like Protein Tyrosine Phosphatases, Class 8
EC 3.1.3.48
Glutamate Decarboxylase
EC 4.1.1.15
glutamate decarboxylase 2 |
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