The role of inertial cavitation in acoustic droplet vaporization

The vaporization of a superheated droplet emulsion into gas bubbles using ultrasound--termed acoustic droplet vaporization (ADV)--has potential therapeutic applications in embolotherapy and drug delivery. The optimization of ADV for therapeutic applications can be enhanced by understanding the physi...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:IEEE transactions on ultrasonics, ferroelectrics, and frequency control. - 1986. - 56(2009), 5 vom: 02. Mai, Seite 1006-17
1. Verfasser: Fabiilli, Mario L (VerfasserIn)
Weitere Verfasser: Haworth, Kevin J, Fakhri, Nasir H, Kripfgans, Oliver D, Carson, Paul L, Fowlkes, J Brian
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:IEEE transactions on ultrasonics, ferroelectrics, and frequency control
Schlagworte:Journal Article Research Support, N.I.H., Extramural Emulsions Fluorocarbons Gases
LEADER 01000naa a22002652 4500
001 NLM188824871
003 DE-627
005 20231223182606.0
007 cr uuu---uuuuu
008 231223s2009 xx |||||o 00| ||eng c
024 7 |a 10.1109/TUFFC.2009.1132  |2 doi 
028 5 2 |a pubmed24n0629.xml 
035 |a (DE-627)NLM188824871 
035 |a (NLM)19473917 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Fabiilli, Mario L  |e verfasserin  |4 aut 
245 1 4 |a The role of inertial cavitation in acoustic droplet vaporization 
264 1 |c 2009 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 15.09.2009 
500 |a Date Revised 20.10.2021 
500 |a published: Print 
500 |a Citation Status MEDLINE 
520 |a The vaporization of a superheated droplet emulsion into gas bubbles using ultrasound--termed acoustic droplet vaporization (ADV)--has potential therapeutic applications in embolotherapy and drug delivery. The optimization of ADV for therapeutic applications can be enhanced by understanding the physical mechanisms underlying ADV, which are currently not clearly elucidated. Acoustic cavitation is one possible mechanism. This paper investigates the relationship between ADV and inertial cavitation (IC) thresholds (measured as peak rarefactional pressures) by studying parameters that are known to influence the IC threshold. These parameters include bulk fluid properties such as gas saturation, temperature, viscosity, and surface tension; droplet parameters such as degree of superheat, surfactant type, and size; and acoustic properties such as pulse repetition frequency and pulse width. In all cases the ADV threshold occurred at a lower rarefactional pressure than the IC threshold, indicating that the phase transition occurs before IC events. The viscosity and temperature of the bulk fluid are shown to influence both thresholds directly and inversely, respectively. An inverse trend is observed between threshold and diameter for droplets in the 1 to 2.5 microm range. Based on a choice of experimental parameters, it is possible to achieve ADV with or without IC 
650 4 |a Journal Article 
650 4 |a Research Support, N.I.H., Extramural 
650 7 |a Emulsions  |2 NLM 
650 7 |a Fluorocarbons  |2 NLM 
650 7 |a Gases  |2 NLM 
700 1 |a Haworth, Kevin J  |e verfasserin  |4 aut 
700 1 |a Fakhri, Nasir H  |e verfasserin  |4 aut 
700 1 |a Kripfgans, Oliver D  |e verfasserin  |4 aut 
700 1 |a Carson, Paul L  |e verfasserin  |4 aut 
700 1 |a Fowlkes, J Brian  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t IEEE transactions on ultrasonics, ferroelectrics, and frequency control  |d 1986  |g 56(2009), 5 vom: 02. Mai, Seite 1006-17  |w (DE-627)NLM098181017  |x 1525-8955  |7 nnns 
773 1 8 |g volume:56  |g year:2009  |g number:5  |g day:02  |g month:05  |g pages:1006-17 
856 4 0 |u http://dx.doi.org/10.1109/TUFFC.2009.1132  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_22 
912 |a GBV_ILN_24 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 56  |j 2009  |e 5  |b 02  |c 05  |h 1006-17