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NLM188824529 |
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DE-627 |
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20231223182605.0 |
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cr uuu---uuuuu |
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231223s2009 xx |||||o 00| ||eng c |
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7 |
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|a 10.1016/j.clim.2009.05.002
|2 doi
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|a pubmed24n0629.xml
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|a (DE-627)NLM188824529
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|a (NLM)19473882
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Cummings, Kara L
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Frequency of gC1qR+CD4+ T cells increases during acute hepatitis C virus infection and remains elevated in patients with chronic infection
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| 264 |
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1 |
|c 2009
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 01.09.2009
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a CD4+ T cell responses are impaired in chronic HCV infection. To determine factor(s) involved in CD4+ T cell dysregulation, we examined the effect of extracellular core on the alteration of CD4+ T cell responses and the cell surface level of core-binding protein, gC1qR on CD4+ T cells from acute HCV patients with resolved and chronic infection. During the acute phase of infection, the frequency of gC1qR+CD4+ T cells increased in both resolved and chronic HCV infection compared to healthy controls. Notably, 6 months later, the frequency of gC1qR+CD4+ T cells maintained elevated in chronic patients compared to that in resolved patients. In addition, TCR stimulation increased the frequency of gC1qR+CD4+ T cells, resulting in core-induced inhibition of T cell responses in both resolved and chronic patients. These results suggest that HCV infection expands gC1qR+CD4+ T cells, which increase the susceptibility to core-mediated immune dysregulation and facilitate the establishment of HCV persistency
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| 650 |
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|a Journal Article
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| 650 |
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4 |
|a Research Support, N.I.H., Extramural
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| 650 |
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7 |
|a C1QBP protein, human
|2 NLM
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| 650 |
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7 |
|a Carrier Proteins
|2 NLM
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| 650 |
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7 |
|a Hepatitis C Antigens
|2 NLM
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| 650 |
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7 |
|a Mitochondrial Proteins
|2 NLM
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| 650 |
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7 |
|a Receptors, Antigen, T-Cell
|2 NLM
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| 650 |
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7 |
|a Viral Core Proteins
|2 NLM
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| 650 |
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7 |
|a core protein p22, Hepatitis C virus
|2 NLM
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| 700 |
1 |
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|a Rosen, Hugo R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hahn, Young S
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 132(2009), 3 vom: 01. Sept., Seite 401-11
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:132
|g year:2009
|g number:3
|g day:01
|g month:09
|g pages:401-11
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2009.05.002
|3 Volltext
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 132
|j 2009
|e 3
|b 01
|c 09
|h 401-11
|