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DE-627 |
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231223s2009 xx ||||| 00| ||chi c |
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|a pubmed25n0628.xml
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|a (DE-627)NLM188496750
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|a (NLM)19439112
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a chi
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| 100 |
1 |
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|a Wang, Yun-xia
|e verfasserin
|4 aut
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|a Effects of hydroxyethyl starch 130/0.4 on P38 mitogen-activated protein kinases signal transduction pathway
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|c 2009
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 11.05.2010
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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|a OBJECTIVE: To observe the effect of hydroxyethyl starch 130/0.4 (voluven) on P38 mitogen-activated protein kinases (MAPK) signal transduction pathway, with the aim of investigating the mechanism of its protective effect on acute lung injury (ALI) due to infection
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|a METHODS: Thirty male Sprague-Dawley (SD) rats were randomly divided into control group, lipopolysaccharide (LPS 10 mg/kg) group, voluven groups (LPS 10 mg/kg, and hydroxyethyl starch 130/0.4 15 ml/kg or 30 ml/kg) and alone voluven group (hydroxyethyl starch 130/0.4 30 ml/kg), with 6 rats in each group. Rats were sacrificed at 6 hours, the lungs were harvested for observation of pathological changes. The expression of p-P38, P38, p-P44/42 and P44/42 were detected with Western blotting. Activating protein-1 (AP-1) activation was measured with electrophoretic mobility shift assay (EMSA)
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|a RESULTS: Compared with control, p-P38, p-P44/42 and AP-1 were significantly higher in LPS group (P<0.05 or P<0.01). The expressions of p-P38 and AP-1 activation were significantly reduced in both voluven groups (all P<0.05). But there was no statistically significant difference between voluven 15 ml/kg and 30 ml/kg groups (all P>0.05)
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|a CONCLUSION: Hydroxyethyl starch 130/0.4 can inhibit LPS-induced ALI by depressing expression of p-P38 and AP-1 activation in lung
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|a English Abstract
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a HES 130-0.4
|2 NLM
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| 650 |
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|a Hydroxyethyl Starch Derivatives
|2 NLM
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|a Lipopolysaccharides
|2 NLM
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| 650 |
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|a Transcription Factor AP-1
|2 NLM
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|a Mitogen-Activated Protein Kinase 1
|2 NLM
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| 650 |
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|a EC 2.7.11.24
|2 NLM
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| 650 |
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|a Mitogen-Activated Protein Kinase 3
|2 NLM
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| 650 |
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|a EC 2.7.11.24
|2 NLM
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| 650 |
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|a p38 Mitogen-Activated Protein Kinases
|2 NLM
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| 650 |
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|a EC 2.7.11.24
|2 NLM
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| 700 |
1 |
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|a Gao, Yuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tian, Jie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Wei-wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Xiang-rui
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 21(2009), 5 vom: 14. Mai, Seite 270-3
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
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|g volume:21
|g year:2009
|g number:5
|g day:14
|g month:05
|g pages:270-3
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_350
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|a AR
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|d 21
|j 2009
|e 5
|b 14
|c 05
|h 270-3
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