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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1021/la8042186
|2 doi
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|a pubmed24n0628.xml
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|a (DE-627)NLM188434607
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|a (NLM)19432493
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Wei, Yang
|e verfasserin
|4 aut
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| 245 |
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|a Benchmark experimental data set and assessment of adsorption free energy for peptide-surface interactions
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|c 2009
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 23.07.2009
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|a Date Revised 20.10.2021
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|a published: Print
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|a Citation Status MEDLINE
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|a With the increasing interest in protein adsorption in fields ranging from bionanotechnology to biomedical engineering, there is a growing need to understand protein-surface interactions at a fundamental level, such as the interaction between individual amino acid residues of a protein and functional groups presented by a surface. However, relatively little data are available that experimentally provide a quantitative, comparative measure of these types of interactions. To address this deficiency, the objective of this study was to generate a database of experimentally measured standard state adsorption free energy (DeltaGoads) values for a wide variety of amino acid residue-surface interactions using a host-guest peptide and alkanethiol self-assembled monolayers (SAMs) with polymer-like functionality as the model system. The host-guest amino acid sequence was synthesized in the form of TGTG-X-GTGT, where G and T are glycine and threonine amino acid residues and X represents a variable residue. In this paper, we report DeltaGoads values for the adsorption of 12 different types of the host-guest peptides on a set of nine different SAM surfaces, for a total of 108 peptide-surface systems. The DeltaGoads values for these 108 peptide-surface combinations show clear trends in adsorption behavior that are dependent on both peptide composition and surface chemistry. These data provide a benchmark experimental data set from which fundamental interactions that govern peptide and protein adsorption behavior can be better understood and compared
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Amino Acids
|2 NLM
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|a Peptides
|2 NLM
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| 650 |
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|a Proteins
|2 NLM
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| 700 |
1 |
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|a Latour, Robert A
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 25(2009), 10 vom: 19. Mai, Seite 5637-46
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:25
|g year:2009
|g number:10
|g day:19
|g month:05
|g pages:5637-46
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| 856 |
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|u http://dx.doi.org/10.1021/la8042186
|3 Volltext
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