Loss of SOCS7 in mice results in severe cutaneous disease and increased mast cell activation

The Suppressor of Cytokine Signaling (SOCS) protein family plays a central role in the negative regulation of cytokine action and has been implicated in the development of atopic diseases. Lack of SOCS7 is associated with severe skin disease in mice. We sought to explore the underlying mechanisms re...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 132(2009), 2 vom: 01. Aug., Seite 277-84
1. Verfasser: Knisz, Judit (VerfasserIn)
Weitere Verfasser: Banks, Alex, McKeag, Lisa, Metcalfe, Dean D, Rothman, Paul B, Brown, Jared M
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Cytokines Immunoglobulin G Interleukin-13 Interleukin-6 Receptors, IgE Receptors, Interleukin-7 mehr... SOCS7 protein, mouse Suppressor of Cytokine Signaling Proteins Tumor Necrosis Factor-alpha interleukin-7 receptor, alpha chain Immunoglobulin E 37341-29-0 Thymic Stromal Lymphopoietin GT0IL38SP4 TSLP protein, mouse