IL-4 receptor as a bridge between the immune system and muscle in experimental myasthenia gravis I : up-regulation of muscle IL-15 by IL-4
The study reported below describes increased expression of IL-4 receptor in cultured rat myocytes following exposure to an antibody reactive with the acetylcholine receptor (AChR). In addition, upon up-regulation of IL-4R, myocytes demonstrated an increased responsiveness to IL-4 by producing increa...
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 132(2009), 2 vom: 15. Aug., Seite 246-56 |
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| Weitere Verfasser: | , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2009
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| Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.) |
| Schlagworte: | Journal Article Research Support, N.I.H., Extramural Antibodies, Monoclonal Ccl2 protein, rat Chemokine CCL2 Interleukin-15 Receptors, Cholinergic Receptors, Interleukin-4 Interleukin-4 207137-56-2 |
| Zusammenfassung: | The study reported below describes increased expression of IL-4 receptor in cultured rat myocytes following exposure to an antibody reactive with the acetylcholine receptor (AChR). In addition, upon up-regulation of IL-4R, myocytes demonstrated an increased responsiveness to IL-4 by producing increased levels of IL-15. Moreover, following passive transfer of AChR antibody into Lewis rats, both the increased IL-4R expression and IL-15 production were also observed in intact skeletal muscle, co-localizing in particular individual muscle fibers; the same muscle fibers also produced the chemokine MCP-1 to which IL-4-producing T cells were attracted. A model is proposed in which these muscle activities participate in disease progression in experimental myasthenia gravis |
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| Beschreibung: | Date Completed 17.09.2009 Date Revised 20.10.2021 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1521-7035 |
| DOI: | 10.1016/j.clim.2009.03.523 |