Decreased DNA methyltransferase levels contribute to abnormal gene expression in "senescent" CD4(+)CD28(-) T cells
A senescent CD4(+)CD28(-) T cell subset develops with aging and in chronic inflammatory diseases like rheumatoid arthritis, and is implicated in plaque rupture and myocardial infarctions. This subset is pro-inflammatory, cytotoxic for endothelial cells, and aberrantly expresses genes like CD70, perf...
Ausführliche Beschreibung
Bibliographische Detailangaben
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 132(2009), 2 vom: 15. Aug., Seite 257-65
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| 1. Verfasser: |
Liu, Ying
(VerfasserIn) |
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| Weitere Verfasser: |
Chen, Yingxuan,
Richardson, Bruce |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2009
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| Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.)
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| Schlagworte: | Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
CD27 Ligand
CD28 Antigens
CD70 protein, human
DNMT3A protein, human
KIR2DL4 protein, human
Receptors, KIR2DL4
Perforin
mehr...
126465-35-8
DNA (Cytosine-5-)-Methyltransferase 1
EC 2.1.1.37
DNA (Cytosine-5-)-Methyltransferases
DNA Methyltransferase 3A
DNMT1 protein, human |
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