Effect of microphase separation on the protein resistance of a polymeric surface

Segmented polyurethanes (PUs) containing poly(ethylene glycol) (PEG), poly(propylene glycol), or poly(dimethylsiloxane) soft segments have been prepared by two-step condensation polymerization. Atom force microscopy observation in air and solution indicates that the segmented PU forms a microphase s...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 25(2009), 16 vom: 18. Aug., Seite 9467-72
1. Verfasser: Ma, Chunfeng (VerfasserIn)
Weitere Verfasser: Hou, Yi, Liu, Shi, Zhang, Guangzhao
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Dimethylpolysiloxanes Polymers Polyurethanes Propylene Glycols Proteins polypropylene glycol 25322-69-4 Serum Albumin, Bovine mehr... 27432CM55Q Polyethylene Glycols 3WJQ0SDW1A baysilon 63148-62-9
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520 |a Segmented polyurethanes (PUs) containing poly(ethylene glycol) (PEG), poly(propylene glycol), or poly(dimethylsiloxane) soft segments have been prepared by two-step condensation polymerization. Atom force microscopy observation in air and solution indicates that the segmented PU forms a microphase separation on the surface. By use of quartz crystal microbalance with dissipation and surface plasmon resonance, we have investigated the adsorption of fibrinogen, bovine serum albumin, and lysozyme on a surface constructed by such a PU in aqueous solution in real time. Our results reveal that the protein resistance of the PUs arises from the hydrated PEG segments instead of microphase separation 
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650 4 |a Research Support, Non-U.S. Gov't 
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650 7 |a Proteins  |2 NLM 
650 7 |a polypropylene glycol  |2 NLM 
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700 1 |a Hou, Yi  |e verfasserin  |4 aut 
700 1 |a Liu, Shi  |e verfasserin  |4 aut 
700 1 |a Zhang, Guangzhao  |e verfasserin  |4 aut 
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