Clonal expansion of B-cells in human systemic lupus erythematosus : evidence from studies before and after therapeutic B-cell depletion

Anti-B-cell therapy may be beneficial for patients with SLE and active proliferative glomerulonephritis. Using genomic DNA, we examined how rituximab-induced transient B-cell depletion affected the composition of immunoglobulin heavy-chain (Ig-VH/DH/JH) repertoire at the time-point of 33-35% B-cell...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 132(2009), 1 vom: 15. Juli, Seite 19-31
1. Verfasser:	Sfikakis, Petros P (VerfasserIn)
Weitere Verfasser:	Karali, Vassiliki, Lilakos, Konstantinos, Georgiou, George, Panayiotidis, Panayiotis
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2009
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Clinical Trial Journal Article Research Support, Non-U.S. Gov't Antibodies, Monoclonal Antibodies, Monoclonal, Murine-Derived Complementarity Determining Regions Immunoglobulin Heavy Chains Immunologic Factors Rituximab 4F4X42SYQ6