Inclusion of tetracycline hydrochloride within supramolecular gels and its controlled release to bovine serum albumin
Three amphiphilic 3,4,5-trihydroxybenzoic derivatives with alkyl chains of different lengths were designed and synthesized. A small amount of these compounds can trap a large quantity of the water-soluble drug tetracycline hydrochloride (TH) within a stable gel in aqueous ethanol. Release experiment...
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1992. - 25(2009), 15 vom: 04. Aug., Seite 8434-8 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2009
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Drug Carriers Gels Water 059QF0KO0R Serum Albumin, Bovine 27432CM55Q Tetracycline F8VB5M810T |
| Zusammenfassung: | Three amphiphilic 3,4,5-trihydroxybenzoic derivatives with alkyl chains of different lengths were designed and synthesized. A small amount of these compounds can trap a large quantity of the water-soluble drug tetracycline hydrochloride (TH) within a stable gel in aqueous ethanol. Release experiments were carried out with solutions of bovine serum albumin (BSA) and various concentrations of L-isoleucine, L-phenylalanine, and L-tryptophan. The results indicate that the release rate of TH for a BSA solution (10 mg/mL) was faster than that with the other solutions because of the strong interaction between TH and BSA. Furthermore, to gain an insight into the release dynamics, we studied the release ratios as a function of the square root of time (t1/2). During the initial 1.75 h, diffusion is the dominant release process in water, whereas intermolecular interaction controls TH release in the BSA solution |
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| Beschreibung: | Date Completed 19.01.2010 Date Revised 16.11.2017 published: Print Citation Status MEDLINE |
| ISSN: | 1520-5827 |
| DOI: | 10.1021/la8043208 |