Early viraemia clearance during antiviral therapy of chronic hepatitis C improves dendritic cell functions

Early viraemia clearance during antiviral therapy of chronic hepatitis C improves dendritic cell functions

Plasma and cellular HCV RNA and core antigen were tested in monocyte-derived DC (MDDC) from chronic hepatitis C patients undergoing treatment with peg-interferon alpha2b/ribavirin. DC allostimulatory capacity, HCV-specific T-cell reactivity and IL-12 production were measured at baseline and treatmen...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 131(2009), 3 vom: 15. Juni, Seite 415-25
1. Verfasser: Pachiadakis, Ioannis (VerfasserIn)
Weitere Verfasser: Chokshi, Shilpa, Cooksley, Helen, Farmakiotis, Dimitrios, Sarrazin, Christoph, Zeuzem, Stefan, Michalak, Tomasz I, Naoumov, Nikolai V
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antigens, Viral Antiviral Agents Interferon alpha-2 Interferon-alpha RNA, Viral Recombinant Proteins Interleukin-12 187348-17-0 mehr... Polyethylene Glycols 3WJQ0SDW1A Ribavirin 49717AWG6K peginterferon alfa-2b G8RGG88B68
Beschreibung
Zusammenfassung:Plasma and cellular HCV RNA and core antigen were tested in monocyte-derived DC (MDDC) from chronic hepatitis C patients undergoing treatment with peg-interferon alpha2b/ribavirin. DC allostimulatory capacity, HCV-specific T-cell reactivity and IL-12 production were measured at baseline and treatment week (TW)12. Using DC and autologous CD4(+)T-cells, obtained at baseline and TW12, we performed cross-over experiments to determine the relative role of DC and/or T-cells for impaired immune reactivity to HCV. HCV RNA and HCV core plasma levels had an impact on DC phenotype and allostimulatory capacity. In contrast, HCV genome/core protein, although detectable in DC from some patients had no effect on DC function. Antiviral immunity at TW12 was not improved in patients who remained HCV RNA positive, while early viraemia clearance (TW12) improved antiviral responses. The cross-over experiment revealed that changes in DC, rather than CD4(+)T cells have a major role for enhanced anti-HCV responses
Beschreibung:Date Completed 09.06.2009
Date Revised 01.12.2018
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2009.02.001