Indole-3-carbinol improves survival in lupus-prone mice by inducing tandem B- and T-cell differentiation blockades
Indole-3-carbinol (I3C), derived from cruciferous vegetables, alters estrogen metabolism. Since lupus is estrogen dependent, we reasoned that I3C might be effective in SLE. I3C significantly thwarted disease progression and prolonged survival in (NZBxNZW) F1 mice. Immunofluorescent and serologic ana...
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Bibliographische Detailangaben
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 131(2009), 3 vom: 01. Juni, Seite 481-94
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| 1. Verfasser: |
Yan, Xiao-Jie
(VerfasserIn) |
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| Weitere Verfasser: |
Qi, Mei,
Telusma, Gloria,
Yancopoulos, Sophia,
Madaio, Michael,
Satoh, Minoru,
Reeves, Westley H,
Teichberg, Saul,
Kohn, Nina,
Auborn, Karen,
Chiorazzi, Nicholas |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2009
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| Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.)
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| Schlagworte: | Journal Article
Research Support, Non-U.S. Gov't
Anticarcinogenic Agents
Autoantibodies
Cytokines
Estrogens
Immunoglobulin G
Indoles
indole-3-carbinol
C11E72455F |
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