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20231223175026.0 |
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231223s2009 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1016/j.clim.2009.02.002
|2 doi
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| 028 |
5 |
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|a pubmed24n0623.xml
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|a (DE-627)NLM186917708
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|a (NLM)19268633
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Lilleri, Daniele
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Human cytomegalovirus-specific CD4+ and CD8+ T cell responses in primary infection of the immunocompetent and the immunocompromised host
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| 264 |
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1 |
|c 2009
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 09.06.2009
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| 500 |
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|a Date Revised 18.05.2009
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The kinetics of primary human cytomegalovirus (HCMV) infection and specific T-cell responses were investigated in 16 immunocompetent pregnant women and 8 solid-organ transplant recipients (SOTR). T-cell responses to whole HCMV and to pp65 and IE-1 peptides were determined by flow cytometry evaluation of IFNgamma production. HCMV-specific CD4(+) and CD8(+) T-cells appeared earlier and simultaneously in immunocompetent subjects, whereas specific CD8(+) T-cells preceded CD4(+) T-cells in half of the SOTR examined. The magnitude of the HCMV-specific T-cell pool was comparable. HCMV load reached peak levels 100-1000 times higher in SOTR than in immunocompetent women, while the virus persisted for months in blood of both groups. T-cells directed to pp65 and IE-1 were only detected in a portion of subjects developing a full T-cell response to the whole virus. Thus, the development of cell-mediated immune response in primary HCMV infection may be missed when looking at pp65 and IE-1 peptide-stimulated T-cells only
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a IE1 protein, cytomegalovirus
|2 NLM
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| 650 |
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7 |
|a Immediate-Early Proteins
|2 NLM
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| 650 |
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7 |
|a Immunosuppressive Agents
|2 NLM
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| 650 |
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7 |
|a Phosphoproteins
|2 NLM
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| 650 |
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7 |
|a Viral Matrix Proteins
|2 NLM
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| 650 |
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7 |
|a cytomegalovirus matrix protein 65kDa
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a Zelini, Paola
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fornara, Chiara
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Comolli, Giuditta
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Revello, Maria Grazia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gerna, Giuseppe
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 131(2009), 3 vom: 20. Juni, Seite 395-403
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:131
|g year:2009
|g number:3
|g day:20
|g month:06
|g pages:395-403
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2009.02.002
|3 Volltext
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|d 131
|j 2009
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|h 395-403
|