Functionalization of polymer microspheres using click chemistry
We describe a new method to covalently link a wide variety of molecules to the surface of colloidal polymer microspheres using the Cu(I)-catalyzed azide-alkyne reaction, most commonly known under the class of reactions identified by the term click chemistry. The method is generic and readily applied...
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1992. - 25(2009), 8 vom: 21. Apr., Seite 4370-6 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2009
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Journal Article Research Support, U.S. Gov't, Non-P.H.S. Azides Colloids Fluorescent Dyes Polymers Polystyrenes Polyethylene Glycols 3WJQ0SDW1A Copper |
| Zusammenfassung: | We describe a new method to covalently link a wide variety of molecules to the surface of colloidal polymer microspheres using the Cu(I)-catalyzed azide-alkyne reaction, most commonly known under the class of reactions identified by the term click chemistry. The method is generic and readily applied to a spectrum of colloidal particle systems allowing surfaces to be tailored with virtually any desired functionality. To demonstrate this method, polystyrene microspheres were functionalized with two different polyethylene oxide-based polymers, and changes in hydrodynamic radii after functionalization were measured using dynamic light scattering. Control of surface functional groups was demonstrated by fluorescently labeling the colloidal microspheres using the same Cu-catalyzed azide-alkyne cycloaddition reaction |
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| Beschreibung: | Date Completed 07.07.2009 Date Revised 01.12.2018 published: Print Citation Status MEDLINE |
| ISSN: | 1520-5827 |
| DOI: | 10.1021/la801880u |