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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1002/mrc.2414
|2 doi
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|a pubmed25n0623.xml
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|a eng
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|a Santa María, Dolores
|e verfasserin
|4 aut
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|a The behavior of Gliclazide in solution and in the solid state
|b a case of organic compound presenting a solid-solution structure
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|c 2009
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|a Text
|b txt
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 10.07.2009
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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|a 2009 John Wiley & Sons, Ltd.
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|a The structure of the hypoglycemic agent Gliclazide has been studied by (1)H, (13)C, and (15)N NMR in solution (CDCl(3) and DMSO-d(6)) and in the solid state. In the solid state, the compound crystallizes as an EZ isomer without dynamic properties. In CDCl(3) solution, the structure is still EZ but with a slow nitrogen inversion about the pyrrolidine nitrogen: two invertomers have been observed and characterized. In DMSO-d(6), the rate is faster and only averaged signals were observed. GIAO calculated absolute shieldings were used to confirm the nature of the observed species. In the solid state, Gliclazide presents the phenomenon of solid-solution with two disordered conformations present in the crystal at a 90:10 ratio
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Hypoglycemic Agents
|2 NLM
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|a Solutions
|2 NLM
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|a Gliclazide
|2 NLM
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|a G4PX8C4HKV
|2 NLM
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|a Claramunt, Rosa M
|e verfasserin
|4 aut
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|a Alkorta, Ibon
|e verfasserin
|4 aut
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|a Elguero, José
|e verfasserin
|4 aut
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 47(2009), 6 vom: 01. Juni, Seite 472-7
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnas
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| 773 |
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|g volume:47
|g year:2009
|g number:6
|g day:01
|g month:06
|g pages:472-7
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|u http://dx.doi.org/10.1002/mrc.2414
|3 Volltext
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