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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1021/la804150p
|2 doi
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|a pubmed24n0622.xml
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|a DE-627
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|e rakwb
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| 041 |
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|a eng
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1 |
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|a Lensink, Marc F
|e verfasserin
|4 aut
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|a Characterization of the cationic DiC(14)-amidine bilayer by mixed DMPC/DiC(14)-amidine molecular dynamics simulations shows an interdigitated nonlamellar bilayer phase
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|c 2009
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 02.06.2009
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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|a DiC(14)-amidine (amidine) is a nonphysiological, cationic lipid that forms stable liposomes under physiological pH and temperature. Cationic lipids have been proposed as delivery vector for DNA, proteins, and drugs. Furthermore, amidine carries at present a particular interest due to its immunomodulatory properties. (1-3) Molecular dynamics simulations reveal a remarkable fluidity in the hydrophobic bilayer core, with a tendency for strong surface curvature, in agreement with the relatively small size of experimentally formed liposomes. The amidine bilayer shows an interdigitated, nonlamellar bilayer phase, with a bilayer thickness of only 2.7 nm and an average area per lipid of 0.83 nm(2). A cluster analysis of the individual lipid structures shows a thermally accessible population of V-shaped lipids, indicative of fusion capabilities with the plasma membrane. Fusion experiments confirm this hypothesis. The results are compared to the zwitterionic DMPC (dimyristoylphosphocholine), which also carries two saturated C(14) tails
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Amidines
|2 NLM
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|a Cations
|2 NLM
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|a Lipid Bilayers
|2 NLM
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|a Myristic Acid
|2 NLM
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|a 0I3V7S25AW
|2 NLM
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|a Dimyristoylphosphatidylcholine
|2 NLM
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|a U86ZGC74V5
|2 NLM
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|a Lonez, Caroline
|e verfasserin
|4 aut
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|a Ruysschaert, Jean-Marie
|e verfasserin
|4 aut
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|a Vandenbranden, Michel
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 25(2009), 9 vom: 05. Mai, Seite 5230-8
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:25
|g year:2009
|g number:9
|g day:05
|g month:05
|g pages:5230-8
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|u http://dx.doi.org/10.1021/la804150p
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