The role of the periaqueductal gray in the modulation of pain in males and females are the anatomy and physiology really that different?

The role of the periaqueductal gray in the modulation of pain in males and females : are the anatomy and physiology really that different?

Anatomical and physiological studies conducted in the 1960s identified the periaqueductal gray (PAG) and its descending projections to the rostral ventromedial medulla (RVM) and spinal cord dorsal horn, as a primary anatomical pathway mediating opioid-based analgesia. Since these initial studies, th...

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Détails bibliographiques
Publié dans:Neural plasticity. - 1998. - 2009(2009) vom: 04., Seite 462879
Auteur principal: Loyd, Dayna R (Auteur)
Autres auteurs: Murphy, Anne Z
Format: Article en ligne
Langue:English
Publié: 2009
Accès à la collection:Neural plasticity
Sujets:Journal Article Research Support, N.I.H., Extramural Review Analgesics, Opioid Gonadal Hormones Morphine 76I7G6D29C
Description
Résumé:Anatomical and physiological studies conducted in the 1960s identified the periaqueductal gray (PAG) and its descending projections to the rostral ventromedial medulla (RVM) and spinal cord dorsal horn, as a primary anatomical pathway mediating opioid-based analgesia. Since these initial studies, the PAG-RVM-spinal cord pathway has been characterized anatomically and physiologically in a wide range of vertebrate species. Remarkably, the majority of these studies were conducted exclusively in males with the implicit assumption that the anatomy and physiology of this circuit were the same in females; however, this is not the case. It is well established that morphine administration produces greater antinociception in males compared to females. Recent studies indicate that the PAG-RVM pathway contributes to the sexually dimorphic actions of morphine. This manuscript will review our anatomical, physiological, and behavioral data identifying sex differences in the PAG-RVM pathway, focusing on its role in pain modulation and morphine analgesia
Description:Date Completed 27.02.2009
Date Revised 20.10.2021
published: Print-Electronic
Citation Status MEDLINE
ISSN:1687-5443
DOI:10.1155/2009/462879