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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1002/mrc.2404
|2 doi
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|a pubmed24n0620.xml
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|a (DE-627)NLM186025149
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|a (NLM)19173350
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Vasu Dev, R
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Identification of degradation products in stressed tablets of Rabeprazole sodium by HPLC-hyphenated techniques
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|c 2009
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 07.05.2009
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|a Date Revised 21.11.2013
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|a published: Print
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|a Citation Status MEDLINE
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|a Copyright (c) 2009 John Wiley & Sons, Ltd.
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|a Three unknown impurities of Rabeprazole, a proton pump inhibitor, were formed in the formulated drug under the stress conditions, [40 degrees C/75% relative humidity (RH) for 6 months] with relative retention times (RRTs) 0.17, 0.22 and 0.28. The Impurity-I (0.17 RRT) was isolated using preparative HPLC and characterized by NMR and MS. The other two impurities, Impurity-II (RRT 0.22) and Impurity-III (RRT 0.28) could not be isolated, hence they are characterized by HPLC-hyphenated techniques, LC-NMR and high-resolution LC-MS. On the basis of the spectral data, the Impurity-I, Impurity-II and Impurity-III were characterized as 1-(1H-benzo[d]imidazol-2-yl)-3-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid, 1H-benzo [d] imidazole-2-sulfonic acid and 4-(3-methoxy propoxy)-3-methyl-2-pyridine carboxylic acid, respectively
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|a Journal Article
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|a 2-Pyridinylmethylsulfinylbenzimidazoles
|2 NLM
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|a Anti-Ulcer Agents
|2 NLM
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| 650 |
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|a Tablets
|2 NLM
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| 650 |
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|a Rabeprazole
|2 NLM
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| 650 |
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|a 32828355LL
|2 NLM
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1 |
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|a Sai Uday Kiran, G
|e verfasserin
|4 aut
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1 |
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|a Venkata Subbaiah, B
|e verfasserin
|4 aut
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|a Suresh Babu, B
|e verfasserin
|4 aut
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|a Moses Babu, J
|e verfasserin
|4 aut
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1 |
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|a Dubey, P K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vyas, K
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 47(2009), 5 vom: 01. Mai, Seite 443-8
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnns
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| 773 |
1 |
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|g volume:47
|g year:2009
|g number:5
|g day:01
|g month:05
|g pages:443-8
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|u http://dx.doi.org/10.1002/mrc.2404
|3 Volltext
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