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NLM185973086 |
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DE-627 |
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20250210033449.0 |
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cr uuu---uuuuu |
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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2008.11.013
|2 doi
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|a pubmed25n0620.xml
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|a (DE-627)NLM185973086
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|a (NLM)19167929
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Jorgensen, Gudmundur H
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Familial aggregation of IgAD and autoimmunity
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| 264 |
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1 |
|c 2009
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 15.05.2009
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|a Date Revised 19.11.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a BACKGROUND: The prevalence of autoimmunity is thought to be increased among IgA deficient (IgAD) individuals. However, it is currently unclear if the two conditions coincide within families
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|a OBJECTIVE: To evaluate the prevalence of autoimmunity among IgAD individuals and their 1 degrees relatives
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|a MATERIAL AND METHODS: A total of 43 IgAD individuals (32 adults and 11 children) and all available 1 degrees relatives were evaluated by a physician. A family history of autoimmunity was obtained, together with physical examination and a structured questionnaire that focused on symptoms and signs suggestive of autoimmunity
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| 520 |
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|a RESULTS: Eight of the 32 (25%) adult IgAD, were found to have definite autoimmunity, with organ specific- and systemic autoimmune diseases equally distributed. None of the IgAD children had autoimmunity. Among the 1 degrees relatives, 27/269 (10%) had autoimmunity, compared to an estimate of 5% in the general population (p<0.05)
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|a CONCLUSION: Autoimmune diseases are highly prevalent in individuals with IgAD and more common in their 1 degrees relatives than expected, thus, suggesting a possible common genetic component
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|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Immunoglobulin A
|2 NLM
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| 700 |
1 |
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|a Thorsteinsdottir, Ingunn
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gudmundsson, Sveinn
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hammarstrom, Lennart
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ludviksson, Bjorn R
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 131(2009), 2 vom: 02. Mai, Seite 233-9
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:131
|g year:2009
|g number:2
|g day:02
|g month:05
|g pages:233-9
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2008.11.013
|3 Volltext
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_11
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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|a AR
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| 952 |
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|d 131
|j 2009
|e 2
|b 02
|c 05
|h 233-9
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