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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2008.11.008
|2 doi
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|a pubmed24n0620.xml
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Huck, Kirsten
|e verfasserin
|4 aut
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|a Memory B-cells in healthy and antibody-deficient children
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|c 2009
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|a Text
|b txt
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|a ƒaComputermedien
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|a Date Completed 01.05.2009
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|a Date Revised 08.12.2009
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|a published: Print-Electronic
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|a ErratumIn: Clin Immunol. 2009 Nov;133(2):285
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|a Citation Status MEDLINE
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|a Recently it has become clear that a reduction of IgD-CD27+ memory B-cells in adult CVID patients correlates with clinical aspects of the disease. However, little is known about B-cell dysregulation in pediatric antibody deficiency. Reference values are essential for the interpretation of B-cell subpopulations in children. We present the clinical and immunophenotypical characterization of 16 children and adolescents with CVID and hypogammaglobulinemia. Reference values for IgD+CD27-, IgD+CD27+ and IgD-CD27+ B-cells in healthy children were established for five age groups. In healthy controls we found a continuous increase in IgD-CD27+ B-cell percentage with age from 1.35-5% of B-cells in the second year of life to 4.1-18.7% in adolescents. Interestingly, in 12/14 antibody-deficient patients memory B-cells are significantly below the age-related 10th percentile. We conclude that the reduction of memory B-cells is a useful additional marker for the detection of children with CVID hypogammaglobulinemia and may contribute to the early presentation
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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1 |
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|a Feyen, Oliver
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ghosh, Sujal
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Beltz, Kathrin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bellert, Sven
|e verfasserin
|4 aut
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| 700 |
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|a Niehues, Tim
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 131(2009), 1 vom: 02. Apr., Seite 50-9
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|x 1521-7035
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|g volume:131
|g year:2009
|g number:1
|g day:02
|g month:04
|g pages:50-9
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|u http://dx.doi.org/10.1016/j.clim.2008.11.008
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