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01000naa a22002652 4500 |
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NLM185921760 |
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DE-627 |
| 005 |
20231223173336.0 |
| 007 |
cr uuu---uuuuu |
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231223s2009 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1016/j.clim.2008.12.002
|2 doi
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| 028 |
5 |
2 |
|a pubmed24n0620.xml
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| 035 |
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|a (DE-627)NLM185921760
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| 035 |
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|a (NLM)19162555
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Tiberti, Claudio
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a GAD and IA-2 autoantibody detection in type 1 diabetic patient saliva
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| 264 |
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1 |
|c 2009
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 15.05.2009
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| 500 |
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|a Date Revised 13.04.2009
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| 500 |
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|a published: Print-Electronic
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| 500 |
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|a Citation Status MEDLINE
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| 520 |
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|a Some attempts have been made in assaying glutamic-acid decarboxylase autoantibodies (GADA) in type 1 diabetic patient (T1DM) saliva. However, these salivary assays did not show sufficient sensitivity and specificity in comparison to serum assays. In this study we evaluated the ability of a fluid-phase (35)S-radioimmunoassay to detect GADA and tyrosine phosphatase 2 autoantibodies (IA-2A) in 70 T1DM, 24 T1DM first degree relatives (FDR) and 76 healthy subject saliva. Paired saliva and serum samples were collected from each subject and analyzed. GADA were detected in 45/70 (64.3%) sera and 43/70 (61.4%) T1DM saliva, respectively. IA-2A were detected in 33/70 (47.1%) sera and 30/70 (42.9%) T1DM saliva, respectively. All FDR serum/saliva samples were autoantibody negative. In conclusion, we here report that GADA and IA-2A are detectable with high sensitivity and specificity in human saliva, a specimen which can be easily collected by non-invasive procedures and may represent a reliable tool for the study of T1DM autoimmunity
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Autoantibodies
|2 NLM
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| 650 |
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7 |
|a ICA512 autoantibody
|2 NLM
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| 650 |
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7 |
|a Glutamate Decarboxylase
|2 NLM
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| 650 |
|
7 |
|a EC 4.1.1.15
|2 NLM
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| 700 |
1 |
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|a Shashaj, Blegina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Verrienti, Antonella
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vecci, Elio Giancarlo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lucantoni, Federica
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Masotti, Donata
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Morano, Susanna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sulli, Nicoletta
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dotta, Francesco
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 131(2009), 2 vom: 02. Mai, Seite 271-6
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:131
|g year:2009
|g number:2
|g day:02
|g month:05
|g pages:271-6
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2008.12.002
|3 Volltext
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