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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2008.11.007
|2 doi
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|a pubmed24n0619.xml
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|a (DE-627)NLM185806295
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|a (NLM)19150256
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|a DE-627
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|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Su, Maureen A
|e verfasserin
|4 aut
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| 245 |
1 |
4 |
|a The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients
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|c 2009
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 01.05.2009
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|a Date Revised 17.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Turner Syndrome patients have an absent second sex chromosome and a predisposition to autoimmune disease. We hypothesized that the autoimmune susceptibility in Turner Syndrome may be due to an alteration in the expression of the X-linked FOXP3 gene. FOXP3 is important in the development of regulatory T cells, and complete loss of FOXP3 expression has been shown to result in severe autoimmunity. To test this hypothesis, we characterized the regulatory T cells and performed immunophenotyping on the peripheral blood leukocytes of a cohort of Turner Syndrome patients. These patients retained regulatory T cell frequency and function despite an increased prevalence of autoimmunity. Immunophenotyping revealed a decrease in the ratio of CD4 to CD8 lymphocytes. These findings suggest that the autoimmune predisposition in Turner Syndrome is not due to alterations in regulatory T cells but may be associated with a change in the proportion of T cell subsets
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| 650 |
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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| 650 |
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7 |
|a FOXP3 protein, human
|2 NLM
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| 650 |
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7 |
|a Forkhead Transcription Factors
|2 NLM
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| 700 |
1 |
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|a Stenerson, Matthew
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Weihong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Putnam, Amy
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Conte, Felix
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bluestone, Jeffrey A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Anderson, Mark S
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 131(2009), 1 vom: 01. Apr., Seite 139-44
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:131
|g year:2009
|g number:1
|g day:01
|g month:04
|g pages:139-44
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2008.11.007
|3 Volltext
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|d 131
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