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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1021/la803616d
|2 doi
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|a pubmed25n0619.xml
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|a (NLM)19140708
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Jiang, Xiaoze
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Fabrication of two types of shell-cross-linked micelles with "inverted" structures in aqueous solution from schizophrenic water-soluble ABC triblock copolymer via click chemistry
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|c 2009
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 31.03.2009
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|a Date Revised 09.03.2009
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|a published: Print
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|a Citation Status PubMed-not-MEDLINE
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|a A well-defined ABC triblock copolymer, poly(2-(2-methoxyethoxy)ethyl methacrylate)-b-poly(2-(dimethylamino)ethyl methacrylate)-b-poly(2-(diethylamino)ethyl methacrylate) (PMEO2MA-b-PDMA-b-PDEA), was synthesized via sequential atom transfer radical polymerization using ethyl 2-bromoisobutyrate as the initiator. Reacting the triblock precursor with propargyl bromide in anhydrous tetrahydrofuran yielded PMEO2MA-b-P(DMA-co-QDMA)-b-PDEA triblock copolymer with "clickable" moieties, where QDMA was quaternized DMA residues. PMEO2MA-b-P(DMA-co-QDMA)-b-PDEA triblock copolymer exhibited "schizophrenic" micellization behavior in aqueous solution, forming three-layer onion-like PMEO2MA-core and PDEA-core micelles upon proper adjustment of the solution pH and temperature. For temperature-induced formation of PMEO2MA-core micelles at acidic pH, the critical micellization temperature can be tuned by incorporating oligo(ethylene glycol) methyl ether methacrylate (OEGMA; the mean degree of polymerization was 8-9) residues into the PMEO2MA block, shifting from 38 to 43 degrees C as the OEGMA contents varied in the range of 0-10 mol %. In both types of micelles, the inner shell layer consisted of the middle P(DMA-co-QDMA) segment. Subsequently, cross-linking with tetra(ethylene glycol) diazide via click chemistry in the presence of copper catalysts led to the facile preparation of two types of shell-cross-linked (SCL) micelles with "inverted" structures in purely aqueous solution. The cores and coronas of SCL micelles exhibited multiresponsive swelling/shrinking and collapse/aggregation behavior, respectively. To the best of our knowledge, this represents the first report of the fabrication of two types of SCL micelles with inverted structures from a single schizophrenic water-soluble triblock copolymer in purely aqueous solution
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|a Journal Article
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1 |
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|a Zhang, Guoying
|e verfasserin
|4 aut
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|a Narain, Ravin
|e verfasserin
|4 aut
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| 700 |
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|a Liu, Shiyong
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 25(2009), 4 vom: 17. Feb., Seite 2046-54
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
1 |
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|g volume:25
|g year:2009
|g number:4
|g day:17
|g month:02
|g pages:2046-54
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|u http://dx.doi.org/10.1021/la803616d
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