Fabrication of two types of shell-cross-linked micelles with "inverted" structures in aqueous solution from schizophrenic water-soluble ABC triblock copolymer via click chemistry
A well-defined ABC triblock copolymer, poly(2-(2-methoxyethoxy)ethyl methacrylate)-b-poly(2-(dimethylamino)ethyl methacrylate)-b-poly(2-(diethylamino)ethyl methacrylate) (PMEO2MA-b-PDMA-b-PDEA), was synthesized via sequential atom transfer radical polymerization using ethyl 2-bromoisobutyrate as the...
| Publié dans: | Langmuir : the ACS journal of surfaces and colloids. - 1985. - 25(2009), 4 vom: 17. Feb., Seite 2046-54 |
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| Auteur principal: | |
| Autres auteurs: | , , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2009
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| Accès à la collection: | Langmuir : the ACS journal of surfaces and colloids |
| Sujets: | Journal Article |
| Résumé: | A well-defined ABC triblock copolymer, poly(2-(2-methoxyethoxy)ethyl methacrylate)-b-poly(2-(dimethylamino)ethyl methacrylate)-b-poly(2-(diethylamino)ethyl methacrylate) (PMEO2MA-b-PDMA-b-PDEA), was synthesized via sequential atom transfer radical polymerization using ethyl 2-bromoisobutyrate as the initiator. Reacting the triblock precursor with propargyl bromide in anhydrous tetrahydrofuran yielded PMEO2MA-b-P(DMA-co-QDMA)-b-PDEA triblock copolymer with "clickable" moieties, where QDMA was quaternized DMA residues. PMEO2MA-b-P(DMA-co-QDMA)-b-PDEA triblock copolymer exhibited "schizophrenic" micellization behavior in aqueous solution, forming three-layer onion-like PMEO2MA-core and PDEA-core micelles upon proper adjustment of the solution pH and temperature. For temperature-induced formation of PMEO2MA-core micelles at acidic pH, the critical micellization temperature can be tuned by incorporating oligo(ethylene glycol) methyl ether methacrylate (OEGMA; the mean degree of polymerization was 8-9) residues into the PMEO2MA block, shifting from 38 to 43 degrees C as the OEGMA contents varied in the range of 0-10 mol %. In both types of micelles, the inner shell layer consisted of the middle P(DMA-co-QDMA) segment. Subsequently, cross-linking with tetra(ethylene glycol) diazide via click chemistry in the presence of copper catalysts led to the facile preparation of two types of shell-cross-linked (SCL) micelles with "inverted" structures in purely aqueous solution. The cores and coronas of SCL micelles exhibited multiresponsive swelling/shrinking and collapse/aggregation behavior, respectively. To the best of our knowledge, this represents the first report of the fabrication of two types of SCL micelles with inverted structures from a single schizophrenic water-soluble triblock copolymer in purely aqueous solution |
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| Description: | Date Completed 31.03.2009 Date Revised 09.03.2009 published: Print Citation Status PubMed-not-MEDLINE |
| ISSN: | 1520-5827 |
| DOI: | 10.1021/la803616d |