|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM185698905 |
| 003 |
DE-627 |
| 005 |
20250210023510.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231223s2009 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2008.11.004
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n0619.xml
|
| 035 |
|
|
|a (DE-627)NLM185698905
|
| 035 |
|
|
|a (NLM)19138884
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Marciano, Renato
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Association of alleles at polymorphic sites in the Osteopontin encoding gene in young type 1 diabetic patients
|
| 264 |
|
1 |
|c 2009
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 01.05.2009
|
| 500 |
|
|
|a Date Revised 17.11.2011
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a The Osteopontin (OPN) encoding gene, SPP1, can be considered as a candidate for genetic susceptibility to type 1 diabetes (T1D) because of its known function in immune response and inflammation. This work aimed to evaluate the role of SPP1 gene in susceptibility to T1D. Patients (238: 130 male, 108 female) and unaffected adult control individuals (137: 68 males and 69 females) have been genotyped for three variants in the SPP1 gene: -156 (G/GG) and -66 (T/G) in the promoter and a biallelic ins/del variant (TG/TGTG) at +245 in the first intron. The G allele at the -66 SNP had significantly higher frequency in controls than T1D patients. Interestingly, case-control comparison in males showed no significant association, whereas the association was confirmed in females. These results suggest that SPP1 can play a role as susceptibility gene, possibly by a sex-specific mechanism acting in the autoimmune process
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
7 |
|a Autoantibodies
|2 NLM
|
| 650 |
|
7 |
|a HLA-DQ Antigens
|2 NLM
|
| 650 |
|
7 |
|a HLA-DQ alpha-Chains
|2 NLM
|
| 650 |
|
7 |
|a HLA-DQ beta-Chains
|2 NLM
|
| 650 |
|
7 |
|a HLA-DQA1 antigen
|2 NLM
|
| 650 |
|
7 |
|a HLA-DQB1 antigen
|2 NLM
|
| 650 |
|
7 |
|a Membrane Glycoproteins
|2 NLM
|
| 650 |
|
7 |
|a SPP1 protein, human
|2 NLM
|
| 650 |
|
7 |
|a Osteopontin
|2 NLM
|
| 650 |
|
7 |
|a 106441-73-0
|2 NLM
|
| 650 |
|
7 |
|a DNA
|2 NLM
|
| 650 |
|
7 |
|a 9007-49-2
|2 NLM
|
| 700 |
1 |
|
|a D'Annunzio, Giuseppe
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Minuto, Nicola
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Pasquali, Lorenzo
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Santamaria, Andrea
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Di Duca, Marco
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Ravazzolo, Roberto
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Lorini, Renata
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 131(2009), 1 vom: 15. Apr., Seite 84-91
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:131
|g year:2009
|g number:1
|g day:15
|g month:04
|g pages:84-91
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2008.11.004
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 131
|j 2009
|e 1
|b 15
|c 04
|h 84-91
|