The cytoprotective role of Ras in complement-mediated glomerular epithelial cell injury
In experimental membranous nephropathy, complement C5b-9-induced glomerular epithelial cell (GEC) injury leads to loss of glomerular permselectivity and proteinuria. Incubation of cultured GEC with antibody and serially-increasing concentrations of complement induced cytotoxicity in a dose-dependent...
Ausführliche Beschreibung
Bibliographische Detailangaben
| Veröffentlicht in: | Clinical immunology (Orlando, Fla.). - 1999. - 131(2009), 2 vom: 03. Mai, Seite 343-53
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| 1. Verfasser: |
Huynh, Carl
(VerfasserIn) |
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| Weitere Verfasser: |
Ren, Guohui,
Papillon, Joan,
Guillemette, Julie,
Takano, Tomoko,
Cybulsky, Andrey V |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2009
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| Zugriff auf das übergeordnete Werk: | Clinical immunology (Orlando, Fla.)
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| Schlagworte: | Journal Article
Research Support, Non-U.S. Gov't
Complement Membrane Attack Complex
Immunologic Factors
Mitogen-Activated Protein Kinases
EC 2.7.11.24
rac GTP-Binding Proteins
EC 3.6.5.2
ras Proteins |
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