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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1111/j.1469-8137.2008.02668.x
|2 doi
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|a pubmed24n0619.xml
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Grönlund, Andreas
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Modular gene expression in Poplar
|b a multilayer network approach
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| 264 |
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1 |
|c 2009
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 10.02.2009
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| 500 |
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|a Date Revised 30.09.2020
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a By applying a multilayer network approach to an extensive set of Poplar microarray data, a genome-wide coexpression network has been detected and explored. Multilayer networks were generated from minimum spanning trees (MSTs) using Kruskal's algorithm from random jack-knife resamplings of half of the full data set. The final network is obtained from the union of all the generated MSTs. The gene expression correlations display a highly clustered topology, which is more pronounced when introducing links appearing in relatively few of the generated MSTs. The network also reveals a modular architecture, reflecting functional groups with relatively frequent gene-to-gene communication. Furthermore, the observed modular structure overlaps with different gene activities in different tissues, and closely related tissues show similar over- and/or under-expression patterns at the modular scale. It is shown that including links that appear in a few of the generated MSTs increases the information quality of the network. In other words, a link may be 'weak' because it reflects rare signaling events rather than merely a signal weakened by noise. The method allows, from comparisons of random 'null networks', tuning to maximize the information obtainable
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|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 700 |
1 |
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|a Bhalerao, Rishikesh P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Karlsson, Jan
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t The New phytologist
|d 1979
|g 181(2009), 2 vom: Jan., Seite 315-322
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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| 773 |
1 |
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|g volume:181
|g year:2009
|g number:2
|g month:01
|g pages:315-322
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| 856 |
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|u http://dx.doi.org/10.1111/j.1469-8137.2008.02668.x
|3 Volltext
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|d 181
|j 2009
|e 2
|c 01
|h 315-322
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