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231223s2009 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2008.10.013
|2 doi
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|a pubmed24n0618.xml
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|a (DE-627)NLM185317782
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|a (NLM)19097824
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Iorio, R
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a T-bet, pSTAT1 and pSTAT3 expression in peripheral blood mononuclear cells during pregnancy correlates with post-partum activation of multiple sclerosis
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|c 2009
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 01.05.2009
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|a Date Revised 06.04.2009
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a In pregnant women affected by multiple sclerosis (MS) we observed increased percentages of CD4(+)CD25(+)Foxp3(+) T regulatory cells at the 1st and the 2nd trimester of gestation that was associated with a decreased T-bet expression in CD4(+) T cells. In women showing clinical relapse and/or new lesions at MRI after delivery we found, a higher expression of T-bet, pSTAT1 and pSTAT3 in CD4(+), CD8(+) T cells and CD14(+) cells, associated with an increase of IFNgamma and IL17 production by PBMC at the 3rd trimester of gestation and after delivery. Our data suggest that the expansion of circulating CD4(+)CD25(+)Foxp3(+) regulatory T cells and the lower expression of T-bet in CD4(+) T cells may account for the decreased MS activity during pregnancy. The expression of T-bet, pSTAT1 and pSTAT3 in peripheral blood CD4(+) and CD8(+) T cells and monocytes could be useful to identify MS patients who will develop a relapse after delivery
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|a Journal Article
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|a FOXP3 protein, human
|2 NLM
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| 650 |
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7 |
|a Forkhead Transcription Factors
|2 NLM
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| 650 |
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7 |
|a Interleukin-17
|2 NLM
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| 650 |
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7 |
|a STAT1 Transcription Factor
|2 NLM
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| 650 |
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7 |
|a STAT1 protein, human
|2 NLM
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| 650 |
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7 |
|a STAT3 Transcription Factor
|2 NLM
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| 650 |
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7 |
|a STAT3 protein, human
|2 NLM
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| 650 |
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7 |
|a T-Box Domain Proteins
|2 NLM
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| 650 |
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7 |
|a T-box transcription factor TBX21
|2 NLM
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| 650 |
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7 |
|a Interleukin-10
|2 NLM
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| 650 |
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7 |
|a 130068-27-8
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a Frisullo, G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nociti, V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Patanella, K A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bianco, A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Marti, A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mirabella, M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tonali, P A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Batocchi, A P
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 131(2009), 1 vom: 09. Apr., Seite 70-83
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:131
|g year:2009
|g number:1
|g day:09
|g month:04
|g pages:70-83
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2008.10.013
|3 Volltext
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|a GBV_USEFLAG_A
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|a AR
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|d 131
|j 2009
|e 1
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|h 70-83
|