X-ray fluorescent CT imaging of cerebral uptake of stable-iodine perfusion agent iodoamphetamine analog IMP in mice

Using X-ray fluorescent computed tomography (XFCT), the in vivo and ex vivo cerebral distribution of a stable-iodine-labeled cerebral perfusion agent, iodoamphetamine analog (127I-IMP), has been recorded in the brains of mice. In vivo cerebral perfusion in the cortex, hippocampus and thalamus was de...

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Veröffentlicht in:Journal of synchrotron radiation. - 1994. - 16(2009), Pt 1 vom: 13. Jan., Seite 57-62
1. Verfasser: Takeda, Tohoru (VerfasserIn)
Weitere Verfasser: Wu, Jin, Thet-Thet-Lwin, Huo, Qingkai, Yuasa, Tetsuya, Hyodo, Kazuyuki, Dilmanian, F Avraham, Akatsuka, Takao
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2009
Zugriff auf das übergeordnete Werk:Journal of synchrotron radiation
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Iodine Isotopes Iofetamine C2A5X08042
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520 |a Using X-ray fluorescent computed tomography (XFCT), the in vivo and ex vivo cerebral distribution of a stable-iodine-labeled cerebral perfusion agent, iodoamphetamine analog (127I-IMP), has been recorded in the brains of mice. In vivo cerebral perfusion in the cortex, hippocampus and thalamus was depicted at 0.5 mm in-plane spatial resolution. Ex vivo XFCT images at 0.25 mm in-plane spatial resolution allowed the visualisation of the detailed structures of these regions. The quality of the XFCT image of the hippocampus was comparable with the 125I-IMP autoradiogram. These results highlight the sensitivity of XFCT and its considerable potential to evaluate cerebral perfusion in small animals without using radioactive agents 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
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700 1 |a Wu, Jin  |e verfasserin  |4 aut 
700 0 |a Thet-Thet-Lwin  |e verfasserin  |4 aut 
700 1 |a Huo, Qingkai  |e verfasserin  |4 aut 
700 1 |a Yuasa, Tetsuya  |e verfasserin  |4 aut 
700 1 |a Hyodo, Kazuyuki  |e verfasserin  |4 aut 
700 1 |a Dilmanian, F Avraham  |e verfasserin  |4 aut 
700 1 |a Akatsuka, Takao  |e verfasserin  |4 aut 
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