Kinetics membrane disruption due to drug interactions of chlorpromazine hydrochloride

Drug-membrane interactions assume considerable importance in pharmacokinetics and drug metabolism. Here, we present the interaction of chlorpromazine hydrochloride (CPZ) with supported phospholipid bilayers. It was demonstrated that CPZ binds rapidly to phospholipid bilayers, disturbing the molecula...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Langmuir : the ACS journal of surfaces and colloids. - 1985. - 25(2009), 2 vom: 20. Jan., Seite 1086-90
1. Verfasser:	Nussio, Matthew R (VerfasserIn)
Weitere Verfasser:	Sykes, Matthew J, Miners, John O, Shapter, Joseph G
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2009
Zugriff auf das übergeordnete Werk:	Langmuir : the ACS journal of surfaces and colloids
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Lipid Bilayers Membranes, Artificial Phospholipids Chlorpromazine U42B7VYA4P