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231223s2007 xx ||||| 00| ||eng c |
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|a pubmed24n0617.xml
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|a (DE-627)NLM185150101
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|a (NLM)19079789
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Ghoroghchian, P Peter
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Controlling Bulk Optical Properties of Emissive Polymersomes Through Intramembranous Polymer-Fluorophore Interactions
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|c 2007
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Revised 05.11.2023
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|a published: Print
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|a Citation Status PubMed-not-MEDLINE
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|a Interdisciplinary investigation at the interface of chemistry, engineering, and medicine has enabled the development of self-assembled nanomaterials with novel biochemical and electro-optical properties. We have recently shown that emissive polymersomes, polymer vesicles incorporating porphyrin-based fluorophores, feature large integrated-emission oscillator strengths and narrow emission bands; these nanoscale assemblies can be further engineered to fluoresce at discrete wavelengths throughout the visible and near-infrared (NIR) spectral domains. As such, emissive polymersomes effectively define an organic-based family of soft-matter quantum-dot analogs that possess not only impressive optical properties, but also tunable physical and biomaterial characteristics relative to inorganic fluorescent nanoparticles.Here, we expand upon our initial studies on poly(ethyleneoxide)-block-poly(butadiene)-based vesicles to examine fluorophore membrane-loading in other polymersome systems. Through modulation of fluorophore ancilliary group substituents and choice of polymer chain chemistries, we are able to predictably control intramembranous polymer-fluorophore interactions; these phenomena, in turn, influence the nature of fluorophore solvation, local dielectric environment, and emission quantum yield within emissive polymersome assemblies. By utilizing different classes of vesicle-generating diblock copolymers, including bioresorbable poly(ethyleneoxide)-block-poly(epsilon-caprolactone) (PEO-b-PCL) and poly(ethyleneoxide)-block-poly(gamma-methyl-epsilon-caprolactone) (PEO-b-PMCL), we ascertain general principles important for engineering nanoscale optical vesicles. Further, this work heralds the first generation of fully-biodegradable fluorescent nanoparticles suitable for deep-tissue in vivo imaging
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|a Journal Article
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1 |
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|a Frail, Paul R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Guizhi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zupancich, John A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bates, Frank S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hammer, Daniel A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Therien, Michael J
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Chemistry of materials : a publication of the American Chemical Society
|d 1998
|g 19(2007), 6 vom: 20. März, Seite 1309-1318
|w (DE-627)NLM098194763
|x 0897-4756
|7 nnns
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| 773 |
1 |
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|g volume:19
|g year:2007
|g number:6
|g day:20
|g month:03
|g pages:1309-1318
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|a AR
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|d 19
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