The role of GLU K5-containing kainate receptors in entorhinal cortex gamma frequency oscillations
Using in vitro brain slices of hippocampus and cortex, neuronal oscillations in the frequency range of 30-80 Hz (gamma frequency oscillations) can be induced by a number of pharmacological manipulations. The most routinely used is the bath application of the broad-spectrum glutamate receptor agonist...
| Publié dans: | Neural plasticity. - 1998. - 2008(2008) vom: 12., Seite 401645 |
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| Auteur principal: | |
| Autres auteurs: | , , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2008
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| Accès à la collection: | Neural plasticity |
| Sujets: | Comparative Study Journal Article Gluk1 kainate receptor Receptors, Kainic Acid |
| Résumé: | Using in vitro brain slices of hippocampus and cortex, neuronal oscillations in the frequency range of 30-80 Hz (gamma frequency oscillations) can be induced by a number of pharmacological manipulations. The most routinely used is the bath application of the broad-spectrum glutamate receptor agonist, kainic acid. In the hippocampus, work using transgenic kainate receptor knockout mice have revealed information about the specific subunit composition of the kainate receptor implicated in the generation and maintenance of the gamma frequency oscillation. However, there is a paucity of such detail regarding gamma frequency oscillation in the cortex. Using specific pharmacological agonists and antagonists for the kainate receptor, we have set out to examine the contribution of kainate receptor subtypes to gamma frequency oscillation in the entorhinal cortex. The findings presented demonstrate that in contrast to the hippocampus, kainate receptors containing the GLU(K5) subunit are critically important for the generation and maintenance of gamma frequency oscillation in the entorhinal cortex. Future work will concentrate on determining the exact nature of the cellular expression of kainate receptors in the entorhinal cortex |
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| Description: | Date Completed 13.07.2009 Date Revised 23.03.2024 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1687-5443 |
| DOI: | 10.1155/2008/401645 |