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231223s2008 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1021/la802876u
|2 doi
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|a pubmed24n0615.xml
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|a DE-627
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|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Duchesne, Laurence
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Robust ligand shells for biological applications of gold nanoparticles
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| 264 |
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1 |
|c 2008
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 23.03.2009
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|a Date Revised 01.12.2018
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a An important point regarding the development of stable biofunctional nanoparticles for biomedical applications is their potential for aspecific interactions with the molecules of the biological environment. Here we report a new self-assembled ligand monolayer system for gold nanoparticles called Mix-matrices, formed by a mixture of HS-PEG and alcohol peptides (peptidols) molecules. Stability of the Mix-capped nanoparticles prepared in various conditions was assessed using tests of increasing stringency. The results highlight the importance of identifying a concentration of ligands sufficiently high to obtain a compact matrix when preparing nanoparticles and that the stability of capped nanoparticles in biological environments cannot be predicted solely on their resistance to electrolyte-induced aggregation. The Mix-capped nanoparticles are resistant to aggregation induced by electrolytes and to aspecific interactions with proteins and ligand exchange. In addition, Mix-matrices allow the easy introduction of a single recognition function per nanoparticle, allowing the specific and stoichiometric labeling of proteins with gold nanoparticles. Therefore, the Mix-matrices provide a useful tool for the development of nanoparticle-based quantitative bioanalytical and imaging techniques, as well as for therapeutic purposes, such as the specific targeting of cancerous cells for photothermal destruction
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Ligands
|2 NLM
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| 650 |
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7 |
|a Membranes, Artificial
|2 NLM
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| 650 |
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7 |
|a Oligopeptides
|2 NLM
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| 650 |
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7 |
|a Polyethylene Glycols
|2 NLM
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| 650 |
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7 |
|a 3WJQ0SDW1A
|2 NLM
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| 650 |
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|a Gold
|2 NLM
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| 650 |
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7 |
|a 7440-57-5
|2 NLM
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| 700 |
1 |
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|a Gentili, Denis
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Comes-Franchini, Mauro
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fernig, David G
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 24(2008), 23 vom: 02. Dez., Seite 13572-80
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:24
|g year:2008
|g number:23
|g day:02
|g month:12
|g pages:13572-80
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|u http://dx.doi.org/10.1021/la802876u
|3 Volltext
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